2. GPCR/G Protein
  3. GLP Receptor
  4. Apraglutide

Apraglutide  (Synonyms: FE 203799)

Cat. No.: HY-P1714 Purity: 99.37%
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Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Apraglutide Chemical Structure

Apraglutide Chemical Structure

CAS No. : 1295353-98-8

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1 mg USD 100 In-stock
5 mg USD 260 In-stock
10 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Apraglutide:

Apraglutide Related Antibodies

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Description

Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].

In Vivo

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg[1].
Dosage: 5 mg/kg/dose.
Administration: Subcutaneously, twice on days 0 and 4 postsurgery.
Result: On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.
Clinical Trial
Molecular Weight

3765.25

Formula

C172H263N43O52
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-{Nle}-{d-Phe}-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2
Sequence Shortening

HGDGSFSDE-{Nle}-{d-Phe}-TILDLLAARDFINWLIQTKITD-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (26.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2656 mL 1.3279 mL 2.6559 mL
5 mM 0.0531 mL 0.2656 mL 0.5312 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.37%

COA (242 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2656 mL 1.3279 mL 2.6559 mL 6.6397 mL
5 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3279 mL
10 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6640 mL
15 mM 0.0177 mL 0.0885 mL 0.1771 mL 0.4426 mL
20 mM 0.0133 mL 0.0664 mL 0.1328 mL 0.3320 mL
25 mM 0.0106 mL 0.0531 mL 0.1062 mL 0.2656 mL
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Apraglutide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apraglutide1295353-98-8FE 203799FE203799FE-203799GLP ReceptorInhibitorinhibitorinhibit

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