2. Anti-infection Metabolic Enzyme/Protease
  3. Antibiotic Endogenous Metabolite
  4. Azelaic acid

Azelaic acid  (Synonyms: Nonanedioic acid)

Cat. No.: HY-B0704 Purity: ≥98.0%
COA Handling Instructions

Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals.

For research use only. We do not sell to patients.

Azelaic acid Chemical Structure

Azelaic acid Chemical Structure

CAS No. : 123-99-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Azelaic acid:

Azelaic acid Related Antibodies

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1 Publications Citing Use of MCE Azelaic acid

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals[1][2].

In Vitro

Azelaic acid (0.5 M; 48 h-7 D) has antimicrobial effect[3].
Azelaic acid (5 M; 24 h) decreases intracellular Reactive Oxygen Species (ROS) levels and increases antioxidant capacity[5].
Azelaic acid (1-100 nM, 24 h) suppresses B16, HMB2, and SK23 cell survival ability in a dose-dependent manner[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azelaic acid Related Antibodies

Cell Viability Assay[3]

Cell Line: Propionibacterium acnes and Staphylococcus epidermidis
Concentration: 0.5 M
Incubation Time: Propionibacterium acnes for 48 h, Staphylococcus epidermidis for 7 D
Result: Exhibited large reduction in viability (at least 40-fold) over 24 h.

Immunofluorescence[5]

Cell Line: HL60, U937, THP-1, and AML-PC cells
Concentration: 5 M
Incubation Time: 24 h
Result: Exhibited markedly decreasing the intracellular ROS levels.

Cell Viability Assay[6]

Cell Line: B16, HMB2, and SK23, CHO
Concentration: 10 nM, 20 nM, 30 nM, 40 nM, 50 nM, 60 nM, 70 nM, 80 nM, 90 nM, 100 nM
Incubation Time: 24 h
Result: Showed significantly reduce in the number of B16, HMB2, and SK23 comparing to CHO.
In Vivo

Azelaic acid (15% gel; Smear; twice daily) in 15% gel is efficacious in people with moderate papulo-pustular[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human with rosacea for 12 weeks[4]
Dosage: 15% gel
Administration: Smear
Result: Showed excellent improvent in 78% of the patients with Azelaic acid.
Clinical Trial
Molecular Weight

188.22

Appearance

Solid

Formula

C9H16O4
CAS No.
SMILES

OC(CCCCCCCC(O)=O)=O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (531.29 mM)

H2O : 2 mg/mL (10.63 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3129 mL 26.5647 mL 53.1293 mL
5 mM 1.0626 mL 5.3129 mL 10.6259 mL
10 mM 0.5313 mL 2.6565 mL 5.3129 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (13.28 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Azelaic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Azelaic acid123-99-9Nonanedioic acidAntibioticEndogenous MetaboliteInhibitorinhibitorinhibit

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