Bay 60-7550
Based on 6 publication(s) in Google Scholar
Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM.
For research use only. We do not sell to patients.
- Purity : 98.39%
- CAS No.: 439083-90-6
- Formula: C27H32N4O4
- Molecular Weight:476.57
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-B0312
DipyridamolePDE Inhibitor -
HY-12501A
ITI-214PDE1 Inhibitor -
HY-109586
BRL-50481PDE Inhibitor -
HY-101312
CilostamidePDE3 Inhibitor -
HY-15025A
Sildenafil citratePDE5 Inhibitor -
HY-104028
BAY 73-6691PDE9A Inhibitor -
HY-12085
ApremilastPDE-4 Inhibitor -
HY-111371
PF-05180999PDE2A Inhibitor -
HY-B0442
VardenafilPDE5 Inhibitor -
HY-117571
ZatolmilastPDE4D Inhibitor -
HY-15444
D159687PDE4D Inhibitor -
HY-15426
PF-04957325PDE8 Inhibitor
Publications Citing Use of MedChemExpress (MCE) Bay 60-7550
More- Eur J Pharmacol. 2021 Jun 15:901:174077. [Abstract]
- Eur J Pharmacol. 2021 Jan 15:891:173768. [Abstract]
- Int J Neuropsychopharmacol. 2022 Nov 17;25(11):936-945. [Abstract]
- ACS Chem Neurosci. 2025 Jul 16;16(14):2629-2638. [Abstract]
- J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
- Psychopharmacology. 2018 Aug;235(8):2377-2385. [Abstract]
Customer Validation & Images
-
In Vivo Efficacy Study
-
WB
-
In Vivo Efficacy Study
-
WB
-
WB
Biological Activity
Description
IC50 & Target
|
PDE2 |
In Vitro
Bay 60-7550 (1 μM) increases cGMP in the neuronal cultures compared with control [F(6,14)=12.97, p<0.05 for Bay 60-7550]. Bay 60-7550 in the presence of NMDA (30 μM) results in further increases in cGMP compared with NMDA alone. The NMDA receptor antagonist MK-801 (10 μM) blocks both Bay 60-7550+NMDA-induced elevation in cGMP in neuronal cultures[1]. Compared with untreated control cells, proliferation of PASMCs from IPAH patients is significantly reduced by BAY 60-7550 (1 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 439083-90-6
-
Appearance Solid
-
Molecular Weight 476.57
-
Formula C27H32N4O4
-
Color White to yellow
-
SMILES
O=C1N=C(NN2C1=C(N=C2[C@@H](CCCC3=CC=CC=C3)[C@@H](C)O)C)CC4=CC=C(C(OC)=C4)OC
-
Synonyms
BAY 607550
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
-
Journal Impact Factor
-
Most Recent
-
Eur J Pharmacol
Bay 60-7550, a PDE2 inhibitor, exerts positive inotropic effect of rat heart by increasing PKA-mediated phosphorylation of phospholamban. [Abstract]2021 Jun 15:901:174077. PMID: 33798601
Bay 60-7550 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2021 Jun 15:901:174077. [Abstract]
Total PLB, p-PLB Ser-16, and p-PLB Thr-17 were examined by western blotting in rat left ventricular myocytes after treatment with Bay 60-7550 (0.1 μM; 30 min). Bay 60-7550 significantly increased PLB Ser-16 phosphorylation without significantly changing PLB Thr-17 phosphorylation or total PLB levels.
-
Eur J Pharmacol
Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway. [Abstract]2021 Jan 15:891:173768. PMID: 33271150
Bay 60-7550 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2021 Jan 15:891:173768. [Abstract]
The effects of Bay 60-7550 (Bay; 0.3-3 mg/kg; i.p.; once daily for 10 days) on the percentages of time spent in the open arms, open arm entries, and freezing time in the elevated plus maze test and contextual fear memory paradigm. Bay 60-7550 at 1 and 3 mg/kg significantly increased the percentages of open arms entries and time spent in open arms and decreased the percentage of freezing time.
Bay 60-7550 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2021 Jan 15:891:173768. [Abstract]
PKA and PKG expression was examined in the hippocampus and amygdala of single-prolonged stress mice after treatment with Bay 60-7550 (Bay; 0.3-3 mg/kg; i.p.; once daily for 10 days). Bay 60-7550 dose-dependently increased PKA levels and prevented the SPS-induced reduction in PKG expression.
-
Int J Neuropsychopharmacol
Inhibition of phosphodiesterase 2 ameliorates post-traumatic stress-induced alcohol intake disorder by regulating cAMP/cGMP signaling. [Abstract]2022 Nov 17;25(11):936-945. PMID: 36124735
Bay 60-7550 purchased from MedChemExpress. Usage Cited in: Int J Neuropsychopharmacol. 2022 Nov 17;25(11):936-945. [Abstract]
Ethanol intake and preference at ethanol were measured in the two-bottle choice test in SPS mice after treatment with Bay 60-7550 (Bay; 0.3-3 mg/kg; i.p.; twice daily for 14 days). Bay 60-7550 at doses of 1 and 3 mg/kg decreased involuntary ethanol drinking at 2 concentrations of 9% and 12% compared with the vehicle-treated SPS group. However, Bay 60-7550 at 3 mg/kg significantly decreased the preference of mice to different concentrations of ethanol.
Bay 60-7550 purchased from MedChemExpress. Usage Cited in: Int J Neuropsychopharmacol. 2022 Nov 17;25(11):936-945. [Abstract]
pCREB, CREB and BDNF levels were examined in the dorsolateral striatum of SPS mice after treatment with Bay 60-7550 (Bay; 3 mg/kg; i.p.; twice daily for 14 days). Treatment of Bay reversed the decreased ratio of pCREB/CREB induced by SPS and significantly reversed this decrease in BDNF level in striatum.
-
ACS Chem Neurosci
Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury. [Abstract]2025 Jul 16;16(14):2629-2638. PMID: 40580118 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878 -
Psychopharmacology
Inhibition of phosphodiesterase 2 by Bay 60-7550 decreases ethanol intake and preference in mice. [Abstract]2018 Aug;235(8):2377-2385. PMID: 29876622
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (209.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (287 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Masood A, et al. Anxiolytic effects of phosphodiesterase-2 inhibitors associated with increased cGMP signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):690-9. [Content Brief]
[2]. Bubb KJ, et al. Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation. 2014 Aug 5;130(6):496-507. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0983 mL | 10.4916 mL | 20.9833 mL | 52.4582 mL |
| 5 mM | 0.4197 mL | 2.0983 mL | 4.1967 mL | 10.4916 mL | |
| 10 mM | 0.2098 mL | 1.0492 mL | 2.0983 mL | 5.2458 mL | |
| 15 mM | 0.1399 mL | 0.6994 mL | 1.3989 mL | 3.4972 mL | |
| 20 mM | 0.1049 mL | 0.5246 mL | 1.0492 mL | 2.6229 mL | |
| 25 mM | 0.0839 mL | 0.4197 mL | 0.8393 mL | 2.0983 mL | |
| 30 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7486 mL | |
| 40 mM | 0.0525 mL | 0.2623 mL | 0.5246 mL | 1.3115 mL | |
| 50 mM | 0.0420 mL | 0.2098 mL | 0.4197 mL | 1.0492 mL | |
| 60 mM | 0.0350 mL | 0.1749 mL | 0.3497 mL | 0.8743 mL | |
| 80 mM | 0.0262 mL | 0.1311 mL | 0.2623 mL | 0.6557 mL | |
| 100 mM | 0.0210 mL | 0.1049 mL | 0.2098 mL | 0.5246 mL |
Bay 60-7550 Related Classifications
HY-14992 Related Classifications
Powered by Bioz