Cimetropium Bromide (Synonyms: DA-3177)

Cat. No.: HY-U00106 Purity: 97.14%: FAQs
Data Sheet SDS COA Handling Instructions

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Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome.

For research use only. We do not sell to patients.

Cimetropium Bromide Chemical Structure

CAS No. : 51598-60-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 72	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 72	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome.

IC₅₀ & Target

mAChR^[1]

In Vitro

Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82^[1]. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID₅₀ of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

438.36

Formula

C₂₁H₂₈BrNO₄

CAS No.

51598-60-8

Appearance

Solid

Color

White to off-white

SMILES

C[N+]1([C@H]2[C@@H](O3)[C@@H]3[C@@H]1C[C@H](OC([C@@H](C4=CC=CC=C4)CO)=O)C2)CC5CC5.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (114.06 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2812 mL	11.4062 mL	22.8123 mL
5 mM	0.4562 mL	2.2812 mL	4.5625 mL
10 mM	0.2281 mL	1.1406 mL	2.2812 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (228.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.14%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (255 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Identification of orally administered cimetropium bromide in the colon of the rat and its possible local spasmolytic effect. [Content Brief]

[2]. Saitoh N, et al. Characterization of antimuscarinic effect of cimetropium bromide in guinea pig ileum. J Smooth Muscle Res. 1997 Feb;33(1):1-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2812 mL	11.4062 mL	22.8123 mL	57.0308 mL
	5 mM	0.4562 mL	2.2812 mL	4.5625 mL	11.4062 mL
	10 mM	0.2281 mL	1.1406 mL	2.2812 mL	5.7031 mL
	15 mM	0.1521 mL	0.7604 mL	1.5208 mL	3.8021 mL
	20 mM	0.1141 mL	0.5703 mL	1.1406 mL	2.8515 mL
	25 mM	0.0912 mL	0.4562 mL	0.9125 mL	2.2812 mL
	30 mM	0.0760 mL	0.3802 mL	0.7604 mL	1.9010 mL
	40 mM	0.0570 mL	0.2852 mL	0.5703 mL	1.4258 mL
	50 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1406 mL
	60 mM	0.0380 mL	0.1901 mL	0.3802 mL	0.9505 mL
	80 mM	0.0285 mL	0.1426 mL	0.2852 mL	0.7129 mL
	100 mM	0.0228 mL	0.1141 mL	0.2281 mL	0.5703 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cimetropium Bromide Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cimetropium51598-60-8DA-3177DA3177DA 3177mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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