1. F 16915

F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation.

For research use only. We do not sell to patients.

F 16915 Chemical Structure

F 16915 Chemical Structure

CAS No. : 92510-91-3

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 1849 In-stock
Solution
10 mM * 1 mL in DMSO USD 1849 In-stock
Oil
1 mg USD 1252 In-stock
5 mg USD 2003 In-stock
10 mg USD 3273 In-stock
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Description

F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation[1].

In Vivo

F 16915 (100 mg/kg; daily oral gavage for 2 months) reduces marked dilation of the left atrial (LA) cavity and the steep decline of left ventricular (LV) contractile function occurring 2 months after infarction and reperfusion in rats[1].
F 16915 (1-5 g/day for 4 weeks) significantly reduces the infarct size and prevents the left ventricular free wall thinning[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (220-300 g) with heart failure induced by occlusion of left descending coronary artery and 2 months reperfusion[1]
Dosage: 100 mg/kg
Administration: Daily oral gavage
Result: Reduced the infarct size.
Prevented the left ventricular free wall thinning.
Reduced the de-phosphorylation of connexin43 from atria tissue.
Molecular Weight

419.60

Formula

C28H37NO2

CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OCC1=CC=CN=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (238.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3832 mL 11.9161 mL 23.8322 mL
5 mM 0.4766 mL 2.3832 mL 4.7664 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3832 mL 11.9161 mL 23.8322 mL 59.5806 mL
5 mM 0.4766 mL 2.3832 mL 4.7664 mL 11.9161 mL
10 mM 0.2383 mL 1.1916 mL 2.3832 mL 5.9581 mL
15 mM 0.1589 mL 0.7944 mL 1.5888 mL 3.9720 mL
20 mM 0.1192 mL 0.5958 mL 1.1916 mL 2.9790 mL
25 mM 0.0953 mL 0.4766 mL 0.9533 mL 2.3832 mL
30 mM 0.0794 mL 0.3972 mL 0.7944 mL 1.9860 mL
40 mM 0.0596 mL 0.2979 mL 0.5958 mL 1.4895 mL
50 mM 0.0477 mL 0.2383 mL 0.4766 mL 1.1916 mL
60 mM 0.0397 mL 0.1986 mL 0.3972 mL 0.9930 mL
80 mM 0.0298 mL 0.1490 mL 0.2979 mL 0.7448 mL
100 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
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Product Name:
F 16915
Cat. No.:
HY-19886
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