1. Others
  2. Others

F 16915 

Cat. No.: HY-19886
Handling Instructions

F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.

For research use only. We do not sell to patients.

F 16915 Chemical Structure

F 16915 Chemical Structure

CAS No. : 92510-91-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1849 In-stock
Estimated Time of Arrival: December 31
1 mg USD 1252 In-stock
Estimated Time of Arrival: December 31
5 mg USD 2003 In-stock
Estimated Time of Arrival: December 31
10 mg USD 3273 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.

In Vivo

F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. Time-dependent changes in blood concentrations of total docosahexaenoic acid (DHA) and nicotinyl alcohol are followed after a single oral administration of F 16915 (300 mg/kg) to male rats. Treatment with F 16915 has no significant effect on body weight: 27.7±2.9 kg and 28.1±1.0 kg before surgery versus 29.2±3.4 kg and 28.8±1.7 kg after in the 1 and 5 g/day groups, respectively. F 16915 administered at 5 g/day for 4 weeks significantly reduces the mean duration of Atrial fibrillation (AF) induced by burst pacing but has no significant effect at 1 g/day. The duration of AF is significantly reduced from 989±111 s in the placebo group to 79±59 s in the presence of F 16915 at 5 g/day. Treatment of 2 months with 100 mg/kg F 16915 also significantly reduces the infarct size[1].

References
Animal Administration
[1]

Male Sprague-Dawley rats weighing 220 to 300 g are used in this study. The rats are anesthetized using isoflurane 3% on O2. Then, the animals are intubated and ventilated at 60 respirations/min (2.5 mL/respiration) while anesthesia is maintained. A left thoracotomy is performed, and a silk suture is placed around the left coronary artery ~1 mm from its origin. The treatment starts just after the surgery. A single administration of 100 mg/kg F 16915 or vehicle (olive oil) is daily administrated orally by force-feeding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

419.60

Formula

C₂₈H₃₇NO₂

CAS No.

92510-91-3

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OCC1=CC=CN=C1)=O

Storage

-20°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
F 16915
Cat. No.:
HY-19886
Quantity:

F 16915

Cat. No.: HY-19886