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Heparastatin 

Cat. No.: HY-100899
Handling Instructions

Heparastatin is a heparanase inhibitor.

For research use only. We do not sell to patients.

Heparastatin Chemical Structure

Heparastatin Chemical Structure

CAS No. : 153758-25-9

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Heparastatin is a heparanase inhibitor.

IC50 & Target

heparanase[1].

In Vitro

Addition of 100 μM of Heparastatin (SF4) completely inhibits the enzyme activity of heparanase at a concentration of 0.15 μg/mL in an in vitro degradation assay. Addition of Heparastatin during the transition process does not affect the phenotypic change of TGF-β-treated cells[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6740 mL 18.3702 mL 36.7404 mL
5 mM 0.7348 mL 3.6740 mL 7.3481 mL
10 mM 0.3674 mL 1.8370 mL 3.6740 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells are cultured with 1 ng/mL TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

272.18

Formula

C₈H₁₁F₃N₂O₅

CAS No.

153758-25-9

SMILES

O=C([[email protected]]1CN[[email protected]](NC(C(F)(F)F)=O)[[email protected]@H](O)[[email protected]]1O)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Heparastatin
Cat. No.:
HY-100899
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Heparastatin

Cat. No.: HY-100899