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IQ-R 

Cat. No.: HY-18675
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IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.

For research use only. We do not sell to patients.

IQ-R Chemical Structure

IQ-R Chemical Structure

CAS No. : 1345445-57-9

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Description

IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore. Target: IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. When administered to A549 cells, IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions, thereby visualizing hypoxic cancer cells by robust fluorescence.

Molecular Weight

576.60

Formula

C₃₄H₂₈N₂O₇

CAS No.

1345445-57-9

SMILES

O=C(C=C1OC)C(N2C)=C(C1=O)C(COC(C3=C(C=CC=C3)C4=C(C=C5)C(OC6=CC(N(C)C)=CC=C64)=CC5=O)=O)=C2C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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IQ-R
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