1. Anti-infection
  2. Bacterial
  3. MUT056399

MUT056399 (Synonyms: Fab-001)

Cat. No.: HY-18169 Purity: 99.99%
Handling Instructions

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

For research use only. We do not sell to patients.

MUT056399 Chemical Structure

MUT056399 Chemical Structure

CAS No. : 1269055-85-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 264 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

IC50 & Target

IC50 value: 12 nM (for S. aureus), 58 nM (for E. coli)[1]

In Vitro

MUT056399 (Fab-001) is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli. MUT056399 is very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC90s between 0.03 and 0.12 μg/ml. MUT056399 is also active against coagulase-negative staphylococci, with MIC90s between 0.12 and 4 μg/ml. MUT056399 is very active against the 118 S. aureus strains tested, including MSSA and MRSA isolates and linezolid-resistant and multidrug-resistant strains, with MIC90s between ≤0.03 and 0.12 μg/ml.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.27

Formula

C₁₅H₁₃F₂NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (105.70 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4098 mL 17.0491 mL 34.0983 mL
5 mM 0.6820 mL 3.4098 mL 6.8197 mL
10 mM 0.3410 mL 1.7049 mL 3.4098 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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MUT056399
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HY-18169
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