Polygonaceae Extract

Melafolone is a potent dual COX-2/EGFR inhibitor with IC₅₀s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research.

1-Hydroxy-8-methoxy-3-methyl-6-O-β-D-glucopyranosyl-anthraquinone is an anthraquinone glucoside found in Polygonum macrophyllum D. Don.

Anhydrolutein II, a carotenoid, is a dehydration product of Lutein (HY-N6947).

2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside (Compound 5) is an orally active chromone glycoside found in the roots of Rumex patientia. 2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related fields such as inflammation and metabolic diseases.

2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases.

Piceatannol 4'-O-glucoside is an antioxidant. Piceatannol 4'-O-glucoside is active against oxidation of the human LDL. Piceatannol 4'-O-glucoside can be isolated from Mexican Bamboo.

Pinosylvin (Standard) is the analytical standard of Pinosylvin. This product is intended for research and analytical applications. Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus species, has anti-bacterial activities. Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells.

Physcion-8-O-(6'-O-malonyl)-glucoside can be extracted from the root tuber of Polygonum multiflorum Thunb.

Diacerein (Standard) is the analytical standard of Diacerein. This product is intended for research and analytical applications. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.

2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos.

Resveratrol-4′-O-(6′′-O-galloyl)-glucopyranoside is a polyphenol glycoside which can be isolated from Rheum tanguticum Maxim.

2-Hydroxypinocembrin is a 2-hydroxyflavanones substrate of flavonoid C-glycosyltransferases.

Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury.

Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine (HY-N0473) and L-DOPA (HY-N0304) with IC₅₀s of 45.23 μM and 189.96 μM, respectively.

(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.

Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase inhibitors which are widely used in the study for type 2 diabetes.

Rhaponticin 2''-O-gallate, as a stilbene glucoside gallate, inhibits NO production.

Rhaponticin 6′′-O-gallate is a stilbene glucoside gallate that can be found in rhizome of Rheum undulatum L. Rhaponticin 6′′-O-gallate inhibits nitric oxide production in lipopolysaccharide-activated macrophages.

Rheumone B possesses antioxidant activity.

1-O-Galloyl-2-O-cinnamoyl-glucose is a natural compound that could be found in R. palmatum L..