Sponge

(+)-12α-Hydroxyisodrimenin (compound 7) is a drimanic sesquiterpene that can be found in sponge Dysidea fusca.

Ianthelliformisamine B diTFA is a bromotyrosine-derived antibacterial agent. Ianthelliformisamine B diTFA is against E. coli and S. aureus strains with MICs of 14.5 μM and 144.7 μM.

Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis.

Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation.

2,4,6,6-Tetramethyl-3(6H)-pyridinone is a natural product that can be isolated from the tropical marine sponge Agelas oroides.

Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.

Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines.

5,9-Tetracosadienoic acid is a long-chain polyunsaturated fatty acid with a Δ⁵,⁹ unsaturated structure.

Norselic acid B is a natural compound that can be isolated from the sponge Crella sp. collected in Antarctica. T. Norselic acid B is active against the Leishmania parasite.

Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria.

Discobahamin A is a cyclic peptide with a side chain, a 24-membered macrocyclic cyclic peptide containing an α-ketoamide functional group, and Antifungal agent. Discobahamin A exists in a new species of the deep-sea sponge genus Discodermia from the Bahamas. Discobahamin A inhibits the growth of yeast-form Candida albicans. Discobahamin A is applicable to research related to Candida albicans infections.

Jaspamycin (Standard) is the analytical standard of Jaspamycin (HY-111759). This product is intended for research and analytical applications. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

Azumamide E is a HDAC inhibitor, with an IC₅₀ of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis.

Methyl 6-bromo-1H-indole-3-carboxylate (Standard) is the analytical standard of Methyl 6-bromo-1H-indole-3-carboxylate (HY-W052289). This product is intended for research and analytical applications. Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with antitumor activity. Methyl 6-bromo-1H-indole-3-carboxylate showed growth inhibition against Staphylococcus epidermidis, exhibiting weak or moderate minimum inhibitory concentrations (MICs).

Methyl 2-(6-bromo-1H-indol-3-yl)acetate (Standard) is the analytical standard of Methyl 2-(6-bromo-1H-indol-3-yl)acetate (HY-W035305). This product is intended for research and analytical applications. Methyl 2-(6-bromo-1H-indol-3-yl)acetate is a natural product derived from marine sources, specifically isolated from Pseudosuberites hyalinus.

Methyl 5-bromo-1H-pyrrole-2-carboxylate (Standard) is the analytical standard of Methyl 5-bromo-1H-pyrrole-2-carboxylate (HY-W006646). This product is intended for research and analytical applications. Methyl 5-bromo-1H-pyrrole-2-carboxylate (Compound 7) is a pyrrole that can be isolated from marine sponges Lissodendotyx sp.

Batzelladine L is a potent Plasmodium falciparum inhibitor (IC₅₀= 0.4 μM). Batzelladine L shows moderate cytotoxicity to HepG2 cells (CC₅₀= 14 μM) with antimalarial properties. Batzelladine L is promising for research of antimalarial agents.

Baculiferins A is a DOPA-derived pyrrole alkaloid. Baculiferins A can be isolated from the Chinese marine sponge Iotrochota baculifera. Baculiferins A have anti-HIV activity.

Bengamide B is an alkaloid with anti-tumor and anti-inflammatory activities. Bengamide B reduces the phosphorylation level of IκBα, thereby blocking the activation of NF-κB. Bengamide B inhibits the proliferation of tumor cells. Bengamide B can be used in research related to inflammatory diseases and cancers.

Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent.