Thymelaeaceae Extract

Iriflophenone 2-O-α-rhamnoside can be isolated from the leaves of Aquilaria sinensis. Iriflophenone 2-O-α-rhamnoside has a half-life value of 2.44 min in rats at the administration of 25 mg/kg.

Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells.

Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM.

7-Methoxyneochamaejasmine A (compound 4) is a compound that can be found in Stellera chamaejasme L.

Isodaphnoretin B can be isolated from the roots of S. chamaejasme.

Trilepisflavan is a flavan, which can be isolated from Trilepisium madagascariense. Trilepisflavan derivates serval analogues with anti-cancer activity against human cancer cells.

Edgeworin is a coumarin compound can be isolated from the root and stem of Edgeworthia.

Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC₅₀ of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells.

AH13, a bi-phenylethychromone, can be isolated from acetone extract of agalwood from Kalimantan.

Isoneochamaejasmin A (INCA), a biflavonoid, is one of main active ingredients in the root of Stellera chamaejasme L.

Genkwanol C, a biflavonoid, has effective antiviral activity against respiratory syncytial virus (RSV) in vitro.

Daphnodorin B is a flavonoid. Daphnodorin B can be isolated from the roots of Daphne genkwa. Daphnodorin B can be used for the research of tumor.

Chamaejasmenin A is a C-3/C-3’’ linkage biflavanone that can be isolated from Stellera chamaejasme L..

(-)-Haplomyrfolin is a natural lignan with anticancer effects.

6,7-Dihydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydrochromone is a natural chromone derivative found in withered wood of Aquilaria sinensis.

Epinortrachelogenin ((-)-Epinortrachelogenin) is a natural lignan found in the plateau medicinal plant Daphne acutiloba Rehd.

(+)-Matairesinol is a lignan. (+)-Matairesinol has no cytotoxic activity for human pancreatic PANC-1 cancer cells.

Sikokianin A is a biflavanone that can be isolated from the root of Stellera chamaejasme. Sikokianin A has antimitotic and antifungal activity to against Pyricularia oryzae.

Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells. Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for P. falciparum) and relatively low cytotoxicity (CC₅₀ of 29.0 μM).

Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and apoptosis in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer.