1. Biochemical Assay Reagents

Photo-lysine (Synonyms: Photo lysine)

Cat. No.: HY-19804
Handling Instructions

Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

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Photo-lysine Chemical Structure

Photo-lysine Chemical Structure

CAS No. : 1863117-91-2

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5 mg USD 600 Get quote
10 mg USD 1080 Get quote
20 mg USD 1800 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

In Vitro

Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 5.8075 mL 29.0377 mL 58.0754 mL
5 mM 1.1615 mL 5.8075 mL 11.6151 mL
10 mM 0.5808 mL 2.9038 mL 5.8075 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

172.19

Formula

C₆H₁₂N₄O₂

CAS No.

1863117-91-2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Photo-lysine
Cat. No.:
HY-19804
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