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  2. Photo-lysine hydrochloride

Photo-lysine hydrochloride 

Cat. No.: HY-19804A
Handling Instructions

Photo-lysine hydrochloride, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

For research use only. We do not sell to patients.

Photo-lysine hydrochloride Chemical Structure

Photo-lysine hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2160 In-stock
Estimated Time of Arrival: December 31
20 mg USD 3600 Get quote
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Photo-lysine hydrochloride, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

In Vitro

Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

245.11

Formula

C₆H₁₄Cl₂N₄O₂

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 40 mg/mL (163.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0798 mL 20.3990 mL 40.7980 mL
5 mM 0.8160 mL 4.0798 mL 8.1596 mL
10 mM 0.4080 mL 2.0399 mL 4.0798 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Photo-lysine hydrochloride
Cat. No.:
HY-19804A
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