RO-7
RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
For research use only. We do not sell to patients.
- CAS No.: 1370241-45-4
- Formula: C24H20F3N3O3S
- Molecular Weight:487.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
11.9 μM
Compound: 76; RO-7
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Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay
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[PMID: 28118010] |
| MDCK | CC50 |
86.2 μM
Compound: 76; RO-7
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Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay
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[PMID: 28118010] |
In Vitro
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1370241-45-4
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Molecular Weight 487.49
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Formula C24H20F3N3O3S
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SMILES
O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RO-7 Related Classifications
HY-112684 Related Classifications
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