Infection

Aspirin Trelamine is a salicylic acid prodrug. Aspirin Trelamine has been used in research related to ischemic stroke, as well as COVID-19-associated acute respiratory distress syndrome (ARDS) and pneumonia.

Masavibart (ZRC3308-A7) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Masavibart can be used in combination with ZRC3308-B10 (HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease.

XT-2 peptide is an antimicrobial peptide derived from skin secretions of Xenopus tropicalis. XT-2 peptide has strong activity against E.coli, the vaule of MIC is 8 μM.

Antibacterial agent 61 (example 27) is a antibacterial agent (extracted from patent WO2013030735A1).

CEF7, Influenza Virus NP (380-388) is a HLA-B^*08 restricted influenza virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes.

Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC₉₉s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively.

Fomivirsen sodium scrambled negative control is the sequence scrambled negative control of Fomivirsen sodium.

CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC₅₀ of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC₅₀s of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC₅₀ of 145.92 μM.

U-75875 is a HIV-1 protease inhibitor. U-75875 can block Gag-Pol protein processing and viral maturation and replication. U-75875 can be used for the research of infection.

Diclazuril sodium (R-64433 sodium) is an anticoccidial agent active in preventing parasitic contamination of livestock and poultry feed. Evaluation of the efficacy of Diclazuril sodium in the treatment of Eimeria infection showed poor performance in sustained levels of oocyst excretion compared with controls. Diclazuril sodium has a significant impact on the pathological effects of young animals in clinical applications.

Antimycobacterial agent-10 (compound 5) is a DNA gyrase inhibitor with anti-bacterial actiity (IC₅₀=96 nM, M. tuberculosis gyrase).

Crexavibart (BMS-986413; C-144-LS) is an IgG1_λ2 antibody that targets the SARS-CoV2 spike (S) glycoprotein receptor-binding domain.

Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated anabolite of Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor. Emtricitabine is antiretroviral agent for HIV and HBV infection.

Galeflaprit (LXE408) fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor.Galeflaprit fumarate has an IC₅₀ of 0.04 μM for L. donovani proteasome and an EC₅₀ of 0.04 μM for L. donovani. Galeflaprit fumarate has a low propensity to cross the blood brain barrier. Galeflaprit fumarate has the potential for visceral leishmaniasis (VL) research.

3′-Omethyl-5′-hydroxydiplacone (compound 2), an C-6-geranylflavonoid, can be isolated from the ethanol extract of Paulownia tomentosa fruits. 3′-Omethyl-5′-hydroxydiplacone has antibacterial activity against Gram-positive bacteria.

Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits.

(±)-PM 92131 is a non-nucleoside HIV-1 inhibitor. (±)-PM 92131 has an anti-HIV-1 activity with IC₅₀s of 45.7 and 53.8 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (±)-PM 92131 can be used for HIV infections research.

Taurodeoxycholate (sodium salt) (Standard) is the analytical standard of Taurodeoxycholate (sodium salt). This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses .

Dihydroabikoviromycin, a secondary metabolite of Streptomyces anulatus, is a polyketide synthase inhibitor.

Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM.