Infection

IO-21 (Compound 3) is a candidate cytoprotective agent. IO-21 exhibits a marked cytoprotective effect. IO-21 shows a potent inhibitory activity against HCl•ethanol-induced lesions. IO-21 shows a MIC of 50 μg/mL against Helicobacter pylori 7795. IO-21 can be used in the research of gastric mucosal ulcers.

Licocoumarone is an active component derived from licorice. Licocoumarone has an IC₅₀ of 12.56 μM and a K_d of 14.90 μM against human DYRK1A. Licocoumarone inhibits NF-κB activation by blocking IκBα degradation and p65 phosphorylation, interferes with MAPK activation via inhibiting phosphorylation, and downregulates the expression of iNOS. Licocoumarone inhibits LPS-induced expression of IL-1β, IL-6 and IL-10; it induces apoptosis of pancreatic cancer cells apoptosis and acts as a neuraminidase inhibitor (IC₅₀ = 27.8 μM). Licocoumarone exhibits anti-inflammatory and antimicrobial activities, with antibacterial activity against Listeria and antifungal activity against Candida parapsilosis. Licocoumarone can be used in studies related to immune and inflammatory diseases, pancreatic cancer, and specific bacterial and fungal infections.

Globotriaosylceramide porcine RBC (Ceramide trihexosides porcine) is a neutral glycosphingolipid belonging to the globoside series of erythrocytes, primarily isolated and extracted from porcine RBC. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. Globotriaosylceramide porcine RBC blocks viral binding to CXCR4/CCR5 co-receptors through competitive binding to the V3 loop region of HIV-1 gp120, thereby inhibiting viral fusion and entry. Globotriaosylceramide porcine RBC is the major cell surface receptor for Shiga toxin. Globotriaosylceramide porcine RBC can be used for research on hemolytic uremic syndrome, HIV-1 infection, and Fabry disease.

Cephalothin (Cephalotin) (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an K_i of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies.

Antitrypanosomal agent 30 (compound 6b) is a trypanocidal agent with extremely low cytotoxicity against mouse macrophages. Antitrypanosomal agent 30 can be used for the research of Chagas disease.

KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC₅₀ values of 62 nM, 55 nM, and 60 nM, respectively.

Antibacterial agent 263 (compound 5a) is a potent antibacterial agent. Antibacterial agent 263 shows antibacterial activity for Streptococcus mutans, Staphylococcus aureus.

S-MGB-234 TFA is a minor groove binder used for African Animal Trypanosomiasis (AAT). S-MGB-234 exhibits excellent in vitro activity against the primary pathogens of AAT: Trypanosoma congolense and Trypanosoma vivax. S-MGB-234 TFA does not show cross-resistance with current diamidine active molecules and is not internalized via the transporters used by diamidines.

Neoenactin B2 has strong anti-yeastlike and filamentous fungal effects.

Oganomycin B is more stable than cephalosporin and resistant to Gram-positive and negative bacteria. And it is more effective against Gram-negative bacteria than Gram-positive bacteria.

Penicillin V (Standard) is the analytical standard of Penicillin V. This product is intended for research and analytical applications. Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis[4].

WQ 2743 is a potent antimicrobial agent.

FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC₅₀ of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei.

Arizonin B1, a microbial metabolite, is an antibiotic with anti-Gram-positive bacterial activities.

Thiophanate-Methyl (Standard) is the analytical standard of Thiophanate-Methyl. This product is intended for research and analytical applications. Thiophanate-Methyl is a systematic fungicide.

NADs-IN-2 is a NADSYN1 inhibitor. NADs-IN-2 also binds to the NaAD subsite within the active site of bacterial NADs, thereby inhibiting enzymatic function. NADs-IN-2 can be used in research related to anthrax and cancer.

SCH-43478 is a non-nucleoside antiviral agent. SCH-43478 shows potent and selective activity against herpes simplex virus type 2 (HSV-2) with an IC₅₀ of 1.8 μg/mL using Vero cells. SCH-43478 demonstrates significant efficacy in the guinea pig genital model of HSV infection.

Elvitegravir-¹³C₆ (GS-9137-¹³C₆) is ¹³C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

M090 is the inhibitor for the hemagglutinin of influenza A Virus, that inhibits various influenza strains with EC₅₀ of micromolar levels.

Hongoquercin A is a sesquiterpene antibiotic. Hongoquercin A has moderate anti-Gram-positive bacteria activity with a MIC of 4-8 μg/mL.