Infection

Antibacterial agent 276 (compound B3) is an antibacterial agent with EC₅₀ values of 1.32 μg/mL and 2.80 μg/mL against Xanthomonas oryzae pv.oryzae and Xanthomonas axonopodis pv.citri，respectively. Antibacterial agent 276 disrupts the intracellular redox balance, and results in the accumulation of reactive oxygen species (ROS) and subsequent induction of apoptosis.

Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis.

DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC₅₀ of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency.

Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research.

L-708906 is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an IC₅₀ value of 12 μM. L-708906 inhibits HIV strains resistant to nonnucleoside or nucleoside reverse transcriptase inhibitors.

Isothiafludine (Standard) is the analytical standard of Isothiafludine (HY-111003). This product is intended for research and analytical applications. Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocK_ing pregenomic RNA encapsidation.

Isatoribine is a TLR7 agonist. Isatoribine is used in the study of chronic hepatitis C virus (HCV) infection.

Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC₅₀: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research.

2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12. X

Ro 14-1761 is a third-generation cephalosporin with antibacterial activity.

Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.

Antiparasitic agent-45 is an orally active schistosomicidal agent against Schistosoma mansoni. Antiparasitic agent-45 exerts schistosomicidal activity against Schistosoma mansoni in mice. Antiparasitic agent-45 does not induce ocular reactions in cats. Antiparasitic agent-45 can be used for the research of schistosomiasis.

Herbicidal agent 10 (compound 3s) is a potent herbicidal agent. Herbicidal agent 10 inhibits SvEPSPS with an IC₅₀ of 7.8 μM.

Dienochlor (Decachlor) is a miticide that inhibits Mexican bean beetle, Epilachna varivestis Mulsant, from laying eggs on pinto beans.

BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection.

1,1,3-Tris (3-indolyl) butane is an indole alkaloid. It is isolated from North Sea bacteria closely related to Vibrio parahaemolyticus. 1,1,3-Tris (3-indolyl) butane shows no activity against a variety of bacteria and fungi.

3',4'-Didehydro-3'-deoxycytidine is an endogenous deoxycytidine analog and antiviral agent. 3',4'-Didehydro-3'-deoxycytidine is a host response marker that can cross the plasma membrane, and it can be used in studies related to COVID-19, dengue fever, Zika virus disease, West Nile virus disease, hepatitis C, and other conditions.

Deprodone is an active compound. Deprodone inhibits key processes such as bacterial cell wall synthesis by interacting with the hydrolase and transferase proteins of methicillin-resistant Staphylococcus aureus (MRSA). Deprodone is used in research on anti-MRSA infection, inflammatory skin disorders, bowel disease, and fatty acid metabolism disorders.

Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candida albicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect.

β-Aflatrem is an insecticide metabolite from the sclerotium of Aspergillus flavus that exhibits significant activity against the corn borer H. zea.