Infection

Cladospolide D is found in the strain of Cladosporium sp. FT-0012. Cladospolide D has the activity against part of fungi.

(+)-trans-Limonene oxide is an antimicrobial essential oil component with activity against Staphylococcus aureus. (+)-trans-Limonene oxide acts as a selective agent for drug-resistant bacterial mutants without increasing the mutation frequency of Staphylococcus aureus USA300. (+)-trans-Limonene oxide can be used in studies of Staphylococcus aureus infection.

6-Prenylindole is an antifungal agent that can be isolated from Streptomyces.

Antiviral agent 76 is an antiviral peptide containing azide groups, which has anti-hepatitis C virus (HCV) activity.

Ravidasvir (PPI-668) is an orally active pan-genotypic NS5A inhibitor and antiviral agent. Ravidasvir exhibits antiviral activity against HCV genotypes 1 to 6, with EC₅₀ values ranging from 0.04 to 1.14 nM. Ravidasvir shows no or extremely low activity against feline infectious peritonitis virus type II. Ravidasvir can be used in research related to hepatitis C virus infection.

Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC₅₀ of approximately 80 nM against Yck2 and a MIC₈₀ of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.

Baumycin B1 is an antitumor antibiotic.

β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC₅₀: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC₅₀: 47.70 μg/mL) and E. coli (IC₅₀: 19.17 μg/mL).

Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect.

2'-Deoxyuridine-1′-¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC₅₀ value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors.

Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections.

Ceftizoxime (Standard) is the analytical standard of Ceftizoxime. This product is intended for research and analytical applications. Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.

(E)-Methyl isoferulate ((E)-Isoferulic acid methyl ester) is a derivative of Cinnamic acid (HY-N0610A) and NO inhibitor, with an IC₅₀ > 100 μM against nitric oxide production. (E)-Methyl isoferulate is isolable from the solid cultures of the edible mushroom Neolentinus lepideus. (E)-Methyl isoferulate exerts mild anticancer effects against liver cancer and leukemia.

Tylosin (Standard) is the analytical standard of Tylosin. This product is intended for research and analytical applications. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.

Monamycin I is an ester peptide antibiotic. Monamycin I has activity against Gram-positive bacteria.

Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III.

3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family. 3-GlcA-28-AraRhaxyl-medicagenate exhibits antifungal activity and causes mortality in rice weevils at doses down to 0.1 mg/mL.

GlcB-IN-1 is an inhibitor of Mycobacterium malate synthase (GlcB) with an IC₅₀ of 1.05 μM. GlcB-IN-1 can be used for the research of tuberculosis.

SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.