Inflammation/Immunology

Embramine is a monoethanolamine used as an antihistamine and anticholinergic.

Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new agent development.

Minocromil (FPL59360) is a new Anti-asthmatic agent.

ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.

LY210073 is a Leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 6.2 nM.

Bunaprolast (U66858) is a potent inhibitor of LTB₄ production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB₂ release.

PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.

3b,7a,17a-Trihydroxyandrost-5-ene is a immune modulator extracted from patent US20030060425.

Timobesone is a topical corticosteroid but never marketed.

SC58451 is a potent and selective Cox-2 inhibitor.

Betamethasone 17-benzoate is a representative steroid, which can be used in the treatment of recurrent aphothous ulcers (RAU).

LTD₄ antagonist 1 is a potent, orally active antagonist of leukotriene D₄ (LTD₄) with a K_i of 0.57 nM.

Heterocyclyl carbamate derivative 1 is a heterocyclyl carbamate derivative that may be used for the research of inflammatory and neurological diseases.

Diarylalkane derivative 1 is used for the research of pancreatitis.

S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.

KP136 (AL136) is an orally effective antiallergic agent. The IC₅₀ is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation.

BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.

AZD 4407 is a potent 5-lipoxygenase inhibitor.

Opigolix (ASP-1707) is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.

CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.