Inflammation/Immunology

FAM labled Donidalorsen sodiumis a FAM labled Donidalorsen sodium (HY-139787A).

C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease.

Foeniculoside I is a stilbene trimer glycoside compound found in Foeniculum vulgare. Foeniculoside I has strong antioxidant activity and moderate hyaluronidase inhibitory activity. Foeniculoside I can be used for the researches of cancer, inflammation and immunology.

PD-L1/HDAC6-IN-1 TFA is an orally active dual inhibitor of PD-L1 and HDAC6, with IC₅₀ values of 26.8 nM and 78 nM, respectively. PD-L1/HDAC6-IN-1 TFA binds to human and murine PD-L1 proteins with high affinity, while it reduces STAT3 phosphorylation and downregulates PD-L1 expression by inhibiting HDAC6, thus blocking the PD-1/PD-L1 interaction. PD-L1/HDAC6-IN-1 TFA exhibits potent anti-tumor activity in a mouse melanoma model. PD-L1/HDAC6-IN-1 is suitable for research on tumor immune regulation related to melanoma.

CSBP ligand 1 (Compound 36) is a ligand of CSBP, with an IC₅₀ of 0.08 μM for CSBP binding. CSBP ligand 1 can inhibit the production of TNF in mice treated with LPS (HY-D1056). CSBP ligand 1 has no significant inhibitory activity against PGHS-1 (IC₅₀: 16 μM) and 5-LO (IC₅₀: 60 μM). CSBP ligand 1 can be used in the research of inflammation-related diseases.

Apigenin-¹³C is the ¹³C-abeled Apigenin (HY-N1201). Apigenin is a competitive CYP2C9 inhibitor with a K_i of 2 μM.

Lorglumide (CR-1409) is a potent cholecystokinin (CCK) receptor antagonist. Lorglumide can be used in the research of pancreatic secretion and growth.

Anti-CD103 Antibody (hCD103.01A) is a monoclonal antibody targeting human CD103 and can be used in cancer immunotherapy and immunological research. Recommend Isotype Controls: human IgG1 kappa, Isotype Control (HY-P99001).

RS-87337 is an orally active piperazine-amidine hybrid class Ia (inhibiting V_max, IC₅₀ = 17 μM)/class III (prolonging ADP90, EC₁₅ = 2 μM) antiarrhythmic agent with selectivity for ventricular conduction. RS-87337 inhibits cardiac sodium channel, thereby reducing the maximum depolarization rate of action potential, with moderate onset and recovery kinetics. RS-87337 reduces cardiac outward potassium conductance (I_K), thus prolonging action potential duration. RS-87337 is applicable to research related to arrhythmia, ventricular arrhythmia, ventricular fibrillation, and myocardial ischemia-reperfusion injury.

PCL-2 is a reactive oxygen species (ROS)-responsive fluorescent probe. PCL-2 reacts with ROS to release 6-hydroxy-2-cyanobenzothiazole (HCBT), which then reacts with D-cysteine ​​to form firefly luciferin in situ. PCL-2 must be used in conjunction with IETDC (HY-D3169) to detect the co-existence of hydrogen peroxide and caspase 8. PCL-2 is applicable to studies related to acute inflammation.

TC-2559 free base is a α4β2 nicotinic acetylcholine receptor (nAChR) agonists with an EC₅₀ of 0.18 μM. TC-2559 free base shows much weaker potencies on the group of b4-containing nAChR subtypes, α2β4, α4β4 and α3β4 receptors, with EC₅₀s in the range of 10-30 µM. TC-2559 free base can increase the discharge of dopamine cells in the ventral tegmental area (VTA) of rats in vitro, enhancing the excitability and aggressive behavior of VTA dopamine neurons. TC-2559 free base inhibits STAT3 to exert anti-inflammatory properties and relieves mice mechanical allodynia and improve rats cognitive deficits. TC-2559 free base can be used for the study of nerve pain.

DPPY (compound 6) is a potent PTK inhibitor with IC₅₀ values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF).

Fenhexamid-butyric acid (Compound FHo) is a hapten designed based on fenhexamid, which can produce monoclonal antibodies with an IC₅₀ value of 0.66-0.93 nM.

W140 hydrobromide is a S1P1 antagonist with the K_i of 2.84 μM, and can enhanceof capillary leakage and restoration of lymphocyte egress.

ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 (IC₅₀ = 0.63 μM) and TLR9 (IC₅₀ = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5). ETI41 potently inhibits endosomal TLR-mediated pro-inflammatory signaling with nanomolar activity in cellular, biophysical and in vivo assays. ETI41 suppresses the expression of inflammation-associated genes and effectively ameliorates symptoms in mouse models of psoriasis, and systemic lupus erythematosus (SLE). ETI41 can be used for autoimmune and inflammatory diseases research.

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.

NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC₅₀ of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056). NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant.

Phenopyrazone (Diphenox), a derivative of Antipyrine (HY-B0171), exhibits oral activity as well as analgesic, antipyretic, anti-inflammatory, and antidiarrheal properties. Phenopyrazone can be used in research related to headache, rheumatism, chronic diarrhea and varicose veins.

Senna extract contains anthraquinone compounds, such as sennosides A and B, which have laxative properties. Sennosides in senna extract can stimulate colon muscles, promote intestinal peristalsis, and relieve constipation.

2'-5' Oligoadenylate Synthetase 1, Human is an enzyme induced by IFNs that is activated by the presence of double-stranded RNA and stimulates the oligomerisation of ATP into 2′,5′-linked oligoadenylates (2-5A). 2'-5' Oligoadenylate Synthetase 1, Human plays an important role in inflammatory immune reactions.