2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W1121912
    Nerylformate 2142-94-1
    Nerylformate is a terpenoid derivative secreted by American house dust mites (Dermatophagoides farinae) and European house dust mites (Dermatophagoides pteronyssinus). Nerylformate has a significant attraction effect on both male and female individuals of the two species of house dust mites. Nerylformate guides the mites to gather together to reduce dehydration and enhance defense. Nerylformate can be used for the research of immunology and inflammation, such as allergic rhinitis.
    Nerylformate
  • HY-W1121939
    Perillyl acetate 15111-96-3
    Perillyl acetate is a monoterpene found in in essential oils of plants and is synthesized from perillyl alcohol (HY-N7000). Perillyl acetate can activate the μ-opioid receptor and exert potent analgesic activity. Perillyl acetate can be used for the research of inflammation and neurological disease such as arthritis.
    Perillyl acetate
  • HY-W1122284
    5,6-Epoxy-β-ionone 23267-57-4 98%
    5,6-Epoxy-β-ionone, a derivative of β-ionone (HY-W015084), is a metabolite of Canthaxanthin (HY-B1960).
    5,6-Epoxy-β-ionone
  • HY-W1128213
    IKZF2-degrader 2 2983841-00-3
    IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology.
    IKZF2-degrader 2
  • HY-W1130442
    DMA4-H228 3091917-64-2
    DMA4-H228 is a highly spleen-targeted, ionizable cationic liposome. DMA4-H228 is used to prepare lipid nanoparticles (LNPs) loaded with mRNA for the delivery of mRNA in vivo.
    DMA4-H228
  • HY-W1130450
    Lipid ND-O1 3096665-79-8
    Lipid ND-O1 is an ether-containing ionizable cationic lipid pKa of 6.6. Lipid ND-O1 can be used to generate lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo. Lipid ND-O1 LNPs can be studied in research on hepatic fibrosis.
    Lipid ND-O1
  • HY-W1130458
    503O8,12 3067564-98-8
    503O8,12 is an ionizable cationic lipidoid that enables mRNA delivery to the spleen and lungs in mice when formulated into lipid nanoparticles with neutral helper lipid DOPE[1].
    503O8,12
  • HY-W127433R
    Isostearic acid (Standard) 2724-58-5
    Isostearic acid (Standard) is the analytical standard of Isostearic acid. This product is intended for research and analytical applications. Isostearic acid is a unique fatty acid. Isostearic acid promotes IL-1 release and Apoptosis. Isostearic acid has potent inflammatory properties. Isostearic acid can be used in pharmaceutical, personal care, and cosmetic applications[1][2].
    Isostearic acid (Standard)
  • HY-W153897R
    N-Methyltyramine (Standard) 370-98-9
    N-Methyltyramine (Standard) is the analytical standard of N-Methyltyramine (HY-W153897). This product is intended for research and analytical applications. N-Methyltyramine is an orally active α2-adrenoreceptor antagonist with an IC50 value of 5.53 μM against rat targets. N-Methyltyramine blocks α2-adrenoreceptors, while inhibiting lipolysis, hyperactivity responses and small intestinal peristalsis in mice. N-Methyltyramine promotes gastrin release and pancreatic juice secretion, upregulates appetite, blood pressure, myocardial contraction frequency and contraction intensity, and increases renal blood flow, renal vascular resistance and mean peripheral arterial resistance. N-Methyltyramine relaxes mouse small intestinal smooth muscle and undergoes biotransformation in vivo to produce adrenaline. N-Methyltyramine can be used in studies related to gastrointestinal diseases.
    N-Methyltyramine (Standard)
  • HY-W168309A
    trans-Caffeic aldehyde 141632-15-7
    Trans-Caffeic aldehyde is a type of phenylpropanoid compound, which was discovered in the secondary metabolites of the actinomycete Acrocarpospora punica. Trans-Caffeic aldehyde does not exhibit inhibitory activity against NO production in the mouse macrophage (RAW 264.7) model induced by LPS (HY-D1056).
    trans-Caffeic aldehyde
  • HY-W251598I
    Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 144-55-8 98%
    Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
    Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500
  • HY-W251598J
    Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard 144-55-8 98%
    Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
    Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard
  • HY-W268542R
    4-Acetylaminoantipyrine (Standard) 83-15-8 98%
    4-Acetylaminoantipyrine (Standard) is the analytical standard of 4-Acetylaminoantipyrine. This product is intended for research and analytical applications. 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation.
    4-Acetylaminoantipyrine (Standard)
  • HY-W300403A
    Cinfenoac disodium 68461-38-1 98%
    Cinfenoac disodium is a chalcone derivative with anti-inflammatory activity and can be used in the study of allergic diseases.
    Cinfenoac disodium
  • HY-W385577A
    (S)-2-Benzylpyrrolidine hydrochloride 98%
    (S)-2-Benzylpyrrolidine hydrochloride (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine hydrochloride attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine hydrochloride alleviates Fentanyl-induced respiratory depression.
    (S)-2-Benzylpyrrolidine hydrochloride
  • HY-W653762A
    Cetirizine N-oxide dihydrochloride
    Cetirizine N-oxide dihydrochloride is an oxidative degradation product of the histamine H1 receptor antagonist Cetirizine (HY-17042).
    Cetirizine N-oxide dihydrochloride
  • HY-W740983S
    Dexamethasone dipropionate-d5
    Dexamethasone dipropionate-d5 is the deuterium labeled Dexamethasone dipropionate. Dexamethasone dipropionate is a Dexamethasone (HY-14648) ester. Dexamethasone dipropionate can be used in the research of osteoarthritis.
    Dexamethasone dipropionate-d5
  • HY-W747910A
    S584 dihydrochloride 19971-73-4
    S584 dihydrochloride is a catechol metabolite of the oral-effective Piribedil (HY-12707), with anti-lipid peroxidation activity. S584 dihydrochloride significantly inhibits lipid peroxidation in rat synaptosomes under basal conditions and Fe³⁺ stimulation. S584 dihydrochloride significantly antagonizes the increase in thiobarbituric acid reactive substances (TBARS) in the brains of mice exposed to high oxygen and under normal air conditions.
    S584 dihydrochloride
  • HY-W748591R
    Cannflavin A (Standard) 76735-57-4
    Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC50 = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line.
    Cannflavin A (Standard)
  • HY-W775009R
    Imidazole salicylate (Standard) 36364-49-5
    Imidazole salicylate (Standard) is the analytical standard of Imidazole salicylate. This product is intended for research and analytical applications. Imidazole salicylate is a nonsteroidal anti-inflammatory drug that can be used to study cirrhosis and ascites.
    Imidazole salicylate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity