2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W778608R
    Quercetin 7-glucuronide (Standard) 38934-20-2
    Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
    Quercetin 7-glucuronide (Standard)
  • HY-W782032B
    3D-Monophosphoryl Lipid A-5 triethylamine 98%
    3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that can be used as an adjuvant for vaccines to enhance their immunogenicity.
    3D-Monophosphoryl Lipid A-5 triethylamine
  • HY-W791994A
    BVL3572S 1258544-63-6
    BVL3572S, a hydroxamic acid derivative, exhibits potent bactericidal activity against Mycobacterium tuberculosis (Mtb) with a MIC90 of 1.7 µM. BVL3572S inhibits pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA to kill Mtb. BVL3572S can be used for tuberculosis (TB) research.
    BVL3572S
  • HY-113468AS1
    3-O-Methyldopa-d3 hydrate 98%
    3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa-d3 hydrate
  • HY-119695AS1
    Simvastatin acid-d9 ammonium 98%
    Simvastatin acid-d9 ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
    Simvastatin acid-d9 ammonium
  • HY-W001083S1
    3-Hydroxyphenylacetic acid-d5 98%
    2-(3-Hydroxyphenyl-2,4,6-d3)acetic-2,2-d2 acid is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid-d5
  • HY-W001083S2
    3-Hydroxyphenylacetic acid-d6
    3-Hydroxyphenylacetic acid-d6 is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid-d6
  • HY-W002004S1
    4-Amino-TEMPO-d17 70588-04-4 98%
    4-Amino-TEMPO-d17 (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17) is the deuterium labeled 4-Amino-TEMPO (HY-W002004). 4-Amino-TEMPO (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable nitroxide radical and N-nucleophile based on TEMPO. 4-Amino-TEMPO has superoxide dismutase-mimetic activity, can protect cells from oxidative damage, and has radioprotective effects. 4-Amino-TEMPO is widely used in fields such as biomedicine, materials science, and industrial production. 4-Amino-TEMPO can be used as a spin label to detect free radicals, an oxidation catalyst in industrial production, and an antioxidant stabilizer for polymers, among others.
    4-Amino-TEMPO-d17
  • HY-W003467S1
    Rabeprazole sulfide-d3 1185084-49-4 98%
    Rabeprazole sulfide-d3 is the deuterium labeled Rabeprazole Sulfide (HY-W003467). Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection.
    Rabeprazole sulfide-d3
  • HY-W009762S1
    L-Lysine6-13C dihydrochloride 1217466-44-8 98%
    L-Lysine6-13C (dihydrochloride) is a 13C-labeled L-Lysine dihydrochloride.
    L-Lysine6-13C dihydrochloride
  • HY-W009762S3
    L-Lysine-d8 dihydrochloride 2330877-90-0 98%
    L-Lysine-d8 (dihydrochloride) is the deuterium labeled L-Lysine dihydrochloride.
    L-Lysine-d8 dihydrochloride
  • HY-W009762S4
    L-Lysine-d9 dihydrochloride 2483831-52-1 98%
    L-Lysine-d9 (dihydrochloride) is the deuterium labeled L-Lysine dihydrochloride.
    L-Lysine-d9 dihydrochloride
  • HY-W009762S5
    L-Lysine-15N2,d9 dihydrochloride 98%
    L-Lysine-15N2,d9 (dihydrochloride) is a 15N-labeled and deuterium labeled L-Lysine dihydrochloride.
    L-Lysine-15N2,d9 dihydrochloride
  • HY-W009762S6
    L-Lysine-15N2 dihydrochloride 98%
    L-Lysine-15N2 (dihydrochloride) is a 15N-labeled L-Lysine dihydrochloride.
    L-Lysine-15N2 dihydrochloride
  • HY-W010708S2
    Cholesteryl palmitate-d31 71826-32-9 98%
    Cholesteryl palmitate-d31 is deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).
    Cholesteryl palmitate-d31
  • HY-W012595AR
    trans-Benzylideneacetone (Standard) 1896-62-4 98%
    trans-Benzylideneacetone (Standard) is the analytical standard of trans-Benzylideneacetone. This product is intended for research and analytical applications. trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].
    trans-Benzylideneacetone (Standard)
  • HY-W014423S7
    L-Histidine-d3 hydrochloride hydrate 98%
    L-Histidine-d3 hydrochloride hydrate is the deuterium labeled L-Histidine hydrochloride hydrate (HY-W014423). L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable.
    L-Histidine-d3 hydrochloride hydrate
  • HY-W014423S8
    L-Histidine-15N3,d5 hydrochloride hydrate 98%
    L-Histidine-15N3,d5 hydrochloride hydrate is the deuterium and 15N labeled L-Histidine hydrochloride hydrate (HY-W014423). L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable.
    L-Histidine-15N3,d5 hydrochloride hydrate
  • HY-W015240S1
    N-Acetyl-L-glutamic acid-d4 98%
    N-Acetyl-L-glutamic acid-d4 is the deuterium labeled N-Acetyl-L-glutamic acid (HY-W015240). N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases.
    N-Acetyl-L-glutamic acid-d4
  • HY-W017443S3
    L-Asparagine-15N2,d3 monohydrate 98%
    L-Asparagine-15N2,d3 monohydrate is the deuterium and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-15N2,d3 monohydrate
Cat. No. Product Name / Synonyms Application Reactivity