DHODH-IN-12
DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1263303-93-0
- Formule: C10H9N3O2
- Masse moléculaire:203.20
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
pKa: 5.07 (DHODH)[1]
Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1263303-93-0
-
Masse moléculaire 203.20
-
Formule C10H9N3O2
-
SMILES
O=C(NC1=CC=C(C)C=C1)/C(C#N)=N/O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHODH-IN-12 Related Classifications
HY-135676 Related Classifications
Powered by Bioz