Metabolic Disease

XEN103 is a SCD1 inhibitor, with IC₅₀s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice.

Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis.

Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure.

Cefprozil-CoA (Cefprozil-coenzyme A) is a coenzyme A derivative.

Probucol-d₆ is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HSD17B13-IN-73 (Compound 85) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of < 0.1 μM for estradiol. HSD17B13-IN-73 can be used for research on liver diseases or metabolic disorders.

Empagliflozin-d₈ is the deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC₅₀ of 3.1 nM for human SGLT-2.

ONO-2506-CoA (ONO-2506-coenzyme A) is a coenzyme A derivative.

Landiolol-d₈ (ONO1101-d₈) is the deuterium labeled Landiolol (HY-100607). Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β₁ adrenergic receptors. Landiolol specifically blocks cardiac β₁ receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.

GLP-1R modulator-1 (Compound 384) is an orally active, potent selective glucagon-like peptide-1 receptor (GLP-1R) agonist. GLP-1R modulator-1 activates G-protein coupled signaling, elevates intracellular cAMP levels, promotes insulin secretion, delays gastric emptying and suppresses appetite. GLP-1R modulator-1 is promising for research of type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).

FAM labled Cibrigirsen sodiumis a FAM labled Cibrigirsen sodium.

Thioproline-CoA (Thioproline-coenzyme A) is a coenzyme A derivative.

Leonuriside B is a hepatoprotective glycoside. Leonuriside B can be found in Chinese motherwort (Leonurus japonicus Houtt). Leonuriside B can be used for the research of liver-related disorders.

Ac-Ala-OH-d₃ is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.

(R)-3-Hydroxystearoyl-CoA ((R)-3-Hydroxystearoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

(Asp28)-Exenatide is a degradation product of exenatide (HY-13443). (Asp28)-Exenatide can be used as a GLP-1R agonist.

Malate dehydrogenase, Porcine, is a dehydrogenase that catalyzes the conversion of malate to oxaloacetate.

(3R,19Z,22Z,25Z,28Z)-3-Hydroxytetratriacontatetraenoyl-CoA ((3R,19Z,22Z,25Z,28Z)-3-Hydroxytetratriacontatetraenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

Citrate Synthase, Pigeon (EC 4.1.3.7) catalyses the conversion of Citrate to acetyl-CoA in the presence of coenzyme-A with the release of H2O and oxaloacetate. Citrate Synthase, Pigeon (EC 4.1.3.7) is inhibited by fluoroacetyl-CoA, palmitoyl-CoA, and citroyl-CoA.

MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC₅₀ of 1.4 μM and a K_i value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells.