Metabolic Disease

GLP-1R modulator-1 (Compound 384) is an orally active, potent selective glucagon-like peptide-1 receptor (GLP-1R) agonist. GLP-1R modulator-1 activates G-protein coupled signaling, elevates intracellular cAMP levels, promotes insulin secretion, delays gastric emptying and suppresses appetite. GLP-1R modulator-1 is promising for research of type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).

Phosphotransacetylase, Bacillus subtilis (EC 2.3.1.8), converts coenzyme A to acetyl-CoA. Phosphotransacetylase is an acyltransferase that transfers groups other than aminoacyl groups. Phosphotransacetylase participates in three metabolic pathways: taurine and hypoturine metabolism, pyruvate metabolism, and propionic acid metabolism.

3-Acetylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase and can be used as a positive control substrates for β-D-glucosidase.

3(S)-Hydroxy-docosa-7,10,13,16,19-all-cis-pentaenoyl-CoA (3(S)-Hydroxy-docosa-7,10,13,16,19-all-cis-pentaenoyl-coenzyme A) is a coenzyme A derivative.

Glycerol-3-phosphate dehydrogenase, Human (GPDH; α-Glycerophosphate dehydrogenase; Glycerol phosphate dehydrogenase) is an NADH-dependent oxidoreductase derived from Human that participates in glycolysis, gluconeogenesis, and the glycerol‑3‑phosphate shuttle metabolic pathway. Glycerol-3-phosphate dehydrogenase, Human uses NADH as a reducing equivalent donor, and its substrate binding relies on the phosphate-binding site in the active center; it catalyzes the reversible reduction of dihydroxyacetone phosphate to L‑α‑glycerol‑3‑phosphate. The catalytic activity of the enzymatic reaction of Glycerol-3-phosphate dehydrogenase, Human is regulated by pH and divalent metal ions. Glycerol-3-phosphate dehydrogenase, Human can be used in metabolism-related studies.

Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent.

5-Methylheptadecanoyl-CoA (5-Methylheptadecanoyl-coenzyme A) is a coenzyme A derivative.

Nendratareotide is a somatostatin analogue.

3-Hydroxybutyrate Dehydrogenase, Alcaligenes faecalis (EC 1.1.1.30) catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, the first step in the conversion of ketone bodies to citric acid, which is then further metabolized via the tricarboxylic acid cycle (Krebs cycle).

Δ4-Dafachronic Acid-d₃ is deuterium labeled Δ4-Dafachronic acid (HY-131492). Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology.

Arctigenin 4'-O-β-gentiobioside is a natural compound.

3-Hydroxy-5-oxohexanoyl-CoA (3-Hydroxy-5-oxohexanoyl-coenzyme A) is an oxo- and hydroxy fatty acyl-CoA.

HSD17B13-IN-60 (Compound 126) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of ≤ 0.1 μM for estradiol. HSD17B13-IN-60 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI).

IUB0271 (acyl-GIP) is a glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist with blood-brain barrier permeability. IUB0271 activates the GIPR signaling pathway, inhibits food intake and weight gain, and induces cFos neuron activation in the area postrema. IUB0271 enhances lipid clearance and induces systemic fatty acid oxidation. IUB0271 improves dyslipidemia, reduces atherosclerotic plaque formation and decreases adipocyte volume. IUB0271 can be used in studies related to obesity, dyslipidemia and atherosclerosis.

14-Methyltricosanoyl-CoA (14-Methyltricosanoyl-coenzyme A) is a coenzyme A derivative.

FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy.

Cycloleucine-CoA (Cycloleucine-coenzyme A) is a coenzyme A derivative.

Clofibric acid (Standard) is the analytical standard of Clofibric acid (HY-B1415). This product is intended for research and analytical applications. Clofibric acid (Chlorofibrinic acid) is an orally active PPARα agonist. Clofibric acid inhibits the fimbriation of Escherichia coli. Clofibric acid increases SOD activity. Clofibric acid lowers blood lipids and prevents experimental pyelonephritis. Clofibric acid has anticancer activity against ovarian cancer. Clofibric acid is also a herbicide. Clofibric acid is used in ovarian cancer, liver cancer, obesity, and urinary tract infection research.

Lacto-N-neodifucohexaose II (LNnDFH II) is a neutral difucosylated human milk oligosaccharide (HMO). Lacto-N-neodifucohexaose II is a characteristic HMO associated with the non-secretor phenotype in human milk, and its concentration pattern is positively correlated with the colonization of B. breve in the infant gut.

Isotridecanoyl-CoA (Isotridecanoyl-coenzyme A) is a coenzyme A derivative.