Metabolic Disease

NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).

San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity.

(3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA ((3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

GLP-1 receptor agonist 22 is an orally active GLP-1 receptor agonist. GLP-1 receptor agonist 22 promotes the accumulation of cAMP. GLP-1 receptor agonist 22 reduces blood glucose levels and inhibits feeding behavior in human glucagon-like peptide-1 receptor knock-in mice. GLP-1 receptor agonist 22 can be used in the research of type 2 diabetes and obesity.

Rennin, Mucor miehei (EC 3.4.23.23) hydrolyzes proteins, preferentially hydrolyzing hydrophobic residues at the P1 and P1' positions. Rennin, Mucor miehei (EC 3.4.23.23) can coagulate milk. Because the P1 position cannot accept lysine, it cannot activate trypsinogen.

N2-Succinyl-L-arginine is a nucleoside metabolite.

Ractopamine-¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees).

2-Aminobenzoylacetyl-CoA (2-Aminobenzoylacetyl-coenzyme A) is an acyl-CoA.

Nitrile hydratase, Rhodococcus erythropolis (EC 4.2.1.84) is a mononuclear iron or non-corrinoid cobalt enzyme that catalyse the hydration of diverse nitriles to their corresponding amides.

4-Oxopentanoyl-CoA (4-Oxopentanoyl-coenzyme A) is a coenzyme A derivative.

Lysosomal α-mannosidase (EC:3.2.1.24) is a low pH-activated exoglycosidase that hydrolyzes α-mannosidic linkages on mannan and N-linked oligosaccharides, and its activation requires Zn²⁺. As the major exoglycosidase in the glycoprotein degradation pathway, lysosomal α-mannosidase cleaves α1,2-, α1,3- and α1,6-mannosidic linkages during a non-random, ordered degradation process to generate Man₁GlcNAc_1-2 for further lysosomal processing. Lysosomal α-mannosidase can be used in studies related to α-mannosidosis.

D-Arabitol-¹³C is the ¹³C labeled D-Arabitol. D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research.

Clofibrate-d₄ is the deuterium labeled Clofibrate. Clofibrate is an agonist of PPAR, with EC50s of 50 μM, ∼500 μM for murine PPARα and PPARγ, and 55 μM, ∼500 μM for human PPARα and PPARγ, respectively.

(7Z,10Z,13Z,16Z)-3-Oxodocosatetraenoyl-CoA ((7Z,10Z,13Z,16Z)-3-Oxodocosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

Oxa(dethia)-CoA (Oxa(dethia)-coenzyme A) is a coenzyme A derivative.

N-Acetyl-L-glutamine-CoA (N-Acetyl-L-glutamine-coenzyme A) is a coenzyme A derivative.

Emodin-1-O-β-gentiobioside is an anthraquinone.

Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research.

Nicotinamide riboside triflate, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside triflate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside triflate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.