Metabolic Disease

(S)-3-Hydroxy-9Z,12Z-octadecadienoyl-CoA ((S)-3-Hydroxy-9Z,12Z-octadecadienoyl-coenzyme A) is a coenzyme A derivative.

3-(Methylthio)acryloyl-CoA (3-(Methylthio)acryloyl-coenzyme A) is an acyl-CoA thioester.

D-Glucose-5-¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

3-Oxo-23-methyltetracosanoyl-CoA (3-Oxo-23-methyltetracosanoyl-coenzyme A) is a derivative of coenzyme A.

Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis.

β-Glucosidase, Clostridium thermocellum (EC 3.2.1.21), is a glucosidase that acts on the β1→4 glycosidic bond connecting two glucose molecules or glucose-substituted molecules (e.g., disaccharide cellobiose). β-Glucosidase is an exonuclease specific for a variety of β-D-glycosidic substrates. β-Glucosidase catalyzes the hydrolysis of the terminal non-reducing residues of β-D-glucosides, releasing glucose.

Tigapotide (PCK-3145) is a synthetic 15-mer peptide derived from prostate-secretory protein, and acts as an antineoplastic agent. Tigapotide inhibits tumor growth, experimental bone metastasis, and malignancy-associated hypocalcemia. Tigapotide induces apoptosis in prostate cancer cells and tumors, and suppresses the growth of prostate cancer cells. Tigapotide inhibits the production of parathyroid hormone-related protein (PTHrP) in tumors and plasma. Tigapotide reduces plasma calcium levels in hypercalcemic tumor-bearing rats. Tigapotide is applicable for the research of prostate cancer and malignancy-associated hypercalcemia.

PF-622 is a selective FAAH inhibitor, and can be used for study of analgesic and anxiolytic/antidepressant.

Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC₅₀ of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model.

Gemcadiol is a potent antilipemic agent. Gemcadiol has the potential for the research of hyperlipoproteinemia.

LXQ-87 is an oral noncompetitive inhibitor of PTP1B with an IC₅₀ of 1.061 μM, showing hypoglycemic activity. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake, making it useful for research on type 2 diabetes.

Phospholipase A2, Honey bee venom (Apis mellifera) (EC 3.1.1.4) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues.

2,2-Dimethyl-butyryl-CoA sodium is a coenzyme A derivative.

PDCoA (Coenzyme A,S-1-pyrenedodecanoate) is a coenzyme A derivative.

2-Carboxylauroyl-CoA (2-Carboxylauroyl-coenzyme A) is a coenzyme A derivative.

Sinapoyl-CoA (Sinapoyl-coenzyme A) is a coenzyme A derivative.

HSD17B13-IN-46 (Compound 351) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of < 0.1 μM for estradiol. HSD17B13-IN-46 can be used for research on liver diseases or metabolic disorders.

(R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].

Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT).

S-(D-Carboxybutyl)-L-homocysteine-CoA (S-(D-Carboxybutyl)-L-homocysteine-coenzyme A) is a coenzyme A derivative.