Metabolic Disease

Ethyl 10(E)-pentadecenoate is an ester product.

1,2-Linolein-3-docosahexaenoin is an acylglycerol.

YM-53601 (Standard) is the analytical standard of YM-53601 (HY-100313A). This product is intended for research and analytical applications. YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation.

JTP-59557 is an orally active, stereospecific noncompetitive inhibitor of type IIb sodium/phosphate cotransporter (NaPi-IIb). JTP-59557 selectively inhibits type IIb-mediated inorganic phosphate uptake, without affecting Na⁺-independent inorganic phosphate transport or Na⁺-dependent D-glucose (HY-B0389) transport. JTP-59557 also suppresses Na⁺-dependent inorganic phosphate transport in intestinal brush border membrane vesicles. JTP-59557 is applicable to research related to hyperphosphatemia and hyperphosphatemia associated with chronic kidney disease.

Epaminurad (Standard) is the analytical standard of Epaminurad (HY-111345). This product is intended for research and analytical applications. Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a K_i of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research.

1,3-Laurin-2-stearin is an acylglycerol.

1-Hexanoin-2-palmitin-3-olein is an acylglycerol.

1,2,3-Tri-13(E)-docosenoyl glycerol (Tribrassidin; TG(22:1/22:1/22:1)) is an orally consumable triglyceride. 1,2,3-Tri-13(E)-docosenoyl glycerol was added to the diet of rats by mixing it with corn oil and undergoing ester exchange to improve its digestion and absorption.

L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.

Cholyl-cadaverine is a polyamine bile amidate.

Lauryl myristoleate is an ester product.

5-Hydroxyisourate is an oxidation product of Uric acid (HY-B2130), which can be catalyzed by 5-hydroxyisourate hydrolase to be converted into 2-oxo-4-hydroxy4-carboxy-5-ureidoimidazoline.

C17 Lactosylceramide (d18:1/17:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

5-Hme-CTP is a monomeric raw material that can be used for nucleic acid synthesis.

1,2-O-Dihexadecyl-sn-glycerol ((S)-2,3-Bis(hexadecyloxy)propan-1-ol) is a saturated dialkyl glyceryl ether with hexadecyl groups at the sn-1 and sn-2 positions that mimics the structure of diacylglycerol.

Tetracosanoyl chloride is an ester product.

N-Heptadecane (Standard) is the analytical standard of N-Heptadecane. This product is intended for research and analytical applications. N-Heptadecane (Heptadecane) is an ester product.

5-Formyl-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.

BAY 59-9435 (Standard) is the analytical standard of BAY 59-9435 (HY-102056). This product is intended for research and analytical applications. BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC₅₀ of 0.023 μM.

CAP m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU is a monomeric raw material that can be used for nucleic acid synthesis.