Metabolic Disease

Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers.

1,3-Dipalmitoyl-2-linoleoyl glycerol is a triacylglycerol that contains Palmitic acid at the sn-1 and sn-3 positions and Linoleic acid.

Tetrahydro-β-carboline (Standard) is the analytical standard of Tetrahydro-β-carboline. This product is intended for research and analytical applications. Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 μM.

13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic acid is an ester product.

Dapagliflozin-d₄ (BMS-512148-d₄) is deuterium labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin induces HIF1 expression and attenuates renal IR injury.

Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).

HSK0935 (Standard) is the analytical standard of HSK0935 (HY-101782). This product is intended for research and analytical applications. HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC₅₀ of 1.3 nM. Antihyperglycemic activities.

Casein K_inase II Inhibitor IV (Standard) is the analytical standard of Casein K_inase II Inhibitor IV (HY-111378). This product is intended for research and analytical applications. Casein K_inase II Inhibitor IV is a potent, ATP-competitive of casein K_inase II inhibitor with an IC₅₀ of 9 nM. Casein K_inase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer.

Myristoleyl oleate is an ester product.

Antioxidant agent-16 (Product 2) has strong antioxidant activity with an IC₅₀ value of 6.93 ppm.

Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury.

Palmoxiric acid (McN-3802) is a carnitine acyltransferase inhibitor and a serum metabolite. Palmoxiric acid prevents acylcarnitine formation and lowers blood glucose levels. Palmoxiric acid can be used in research on diabetes and hyperglycemia.

TG (16:0_18:2_20:4) is a monoarachidonic triglyceride, belonging to the triacylglycerol lipid class.

1,2-Cyclohexanedione is an endogenous metabolite.

Methyl trans-11-eicosenoate is an unsaturated fatty acid methyl ester (FAME).

Myristyl stearate is an ester product.

1-Myristoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains Myristic acid (HY-N2041) at the sn-1 position and Oleic acid (HY-N1446) at the sn-3 position.

Citriniorl A is a SIRT1 enhancer with an EC₅₀ of 5.8 μM. Citriniorl A binds to key amino acid residues in the SIRT1 active site to stabilize binding and enhance SIRT1-mediated deacetylation. Citriniorl A can be used for the research of metabolic disorders.

Octadecanoyl coenzyme A (Octadecanoyl-CoA) is an ester product.

Velusetrag (Standard) is the analytical standard of Velusetrag (HY-10457). This product is intended for research and analytical applications. Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pK_i of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease.