1. Membrane Transporter/Ion Channel
  2. SGLT
  3. HSK0935

HSK0935 (Synonyms: HSK-0935; HSK 0935)

Cat. No.: HY-101782
Handling Instructions

HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities.

For research use only. We do not sell to patients.

HSK0935 Chemical Structure

HSK0935 Chemical Structure

CAS No. : 1638851-44-1

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Description

HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities[1].

IC50 & Target

IC50: 1.3 nM (SGLT2)[1]

In Vitro

HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold[1].

In Vivo

HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague−Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1].

HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs[1].

Molecular Weight

436.88

Formula

C₂₂H₂₅ClO₇

CAS No.

1638851-44-1

SMILES

ClC(C=C1)=C(CC2=CC=C(OCC)C=C2)C=C1[[email protected]@]3(OC4)[[email protected]](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@]4(OC)O3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HSK0935
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