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Cat. No.: HY-114460

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SHP2-IN-1

SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC₅₀ of 3 nM.

For research use only. We do not sell to patients.

CAS No.: 1801764-90-8
Formula: C₁₈H₂₂Cl₂N₆OS
Molecular Weight:441.38

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SHP2-IN-1 Chemical Structure

CAS No.: 1801764-90-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC₅₀ of 3 nM.

IC₅₀ & Target

IC50: 3 nM (SHP2)^[1].

Chemical Information

CAS No. 1801764-90-8
Appearance Solid
Molecular Weight 441.38
Formula C₁₈H₂₂Cl₂N₆OS
Color Light yellow to yellow
SMILES

O[C@H]1CC2(CCN(C3=NC(N)=C(SC4=C(Cl)C(Cl)=NC=C4)N=C3)CC2)[C@H](N)C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. WO2018130928A1.

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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