ATR Activator
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2,2'-Thiodiacetic acid
0 ImagesSynonyms: Thiodiglycolic acid2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a metabolite of the anticancer agent Ifosfamide (HY-17419). 2,2'-Thiodiacetic acid is also a biomarker of vinyl chloride monomer exposure in urine. 2,2'-Thiodiacetic acid increases the DNA damage response markers γH2AX, pCHK1, and pATR. 2,2'-Thiodiacetic acid induces Mitochondrial dysfunction. 2,2'-Thiodiacetic acid can be used in research on non-alcoholic fatty liver disease.
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Garcinone C
0 ImagesGarcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
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2,2'-Thiodiacetic acid-d4
0 ImagesCat. No.: HY-W012583SCAS No.: 132090-51-82,2'-Thiodiacetic acid-d4 is the d4-labeled 2,2'-Thiodiacetic acid (HY-W012583). 2,2'-Thiodiacetic acid (Thiodiglycolic acid) is a metabolite of the anticancer agent Ifosfamide (HY-17419). 2,2'-Thiodiacetic acid is also a biomarker of vinyl chloride monomer exposure in urine. 2,2'-Thiodiacetic acid increases the DNA damage response markers γH2AX, pCHK1, and pATR. 2,2'-Thiodiacetic acid induces Mitochondrial dysfunction. 2,2'-Thiodiacetic acid can be used in research on non-alcoholic fatty liver disease.
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Americanin A
0 ImagesCat. No.: HY-N18301CAS No.: 69506-79-2Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer.
