DNA Methyltransferase
DNMTs; DNA MTases
DNA methyltransferases (DNMTs) are a family of “writer” enzymes responsible for DNA methylation that is the addition of a methyl group to the carbon atom number five (C5) of cytosine. Mammalians encode five DNMTs: DNMT1, DNMT2, DNMT3A-DNMT3B (de novo methyltransferases), and DNMTL. DNMT1, DNMT3A, and DNMT3B are the three active enzymes that maintain DNA methylation. DNMT3L has no catalytic activity and functions as a regulator of DNMT3A and DNMT3B, whereas DNMT2 acts as a tRNA transferase rather than a DNA methyltransferase.
DNA methylation is a vital modification process in the control of genetic information, which contributes to the epigenetics by regulating gene expression without changing the DNA sequence. In prokaryotes, DNA methylation is essential for transcription, the direction of post-replicative mismatch repair, the regulation of DNA replication, cell-cycle control, bacterial virulence, and differentiating self and non-self DNA. In mammalians, DNA methylation is crucial in many key physiological processes, including the inactivation of the X-chromosome, imprinting, and the silencing of germline-specific genes and repetitive elements.
DNA Methyltransferase アイソフォーム特異的製品
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DNA Methyltransferase 関連製品 (152)
関連製品 (152)
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抗体 (11)
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DNA Methyltransferase Isoform Comparison
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DNMT2-IN-1
0 Images製品番号: HY-154867DNMT2-IN-1 (compound 80) is a potent and selective DNMT2 (DNA methyltransferase 2) inhibitor with an IC50 value of 1.2 μM, and has the potential for mental and metabolic disorders or cancer research.
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ZIKV-IN-3
0 Images製品番号: HY-151446CAS 番号: 947699-46-9ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).
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(4aS,8aR)-NPD-001
0 Images製品番号: HY-150025CAS 番号: 2366272-43-5(4aS,8aR)-NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS,8aR)-NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS,8aR)-NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS,8aR)-NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882.
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AluI Methyltransferase
0 Images製品番号: HY-E70204CAS 番号: 92228-38-1別名: AluIAluI Methyltransferase (AluI) is a methyltransferase used as the interference enzymes to investigate the selectivity.
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p53 Activator 13
0 Images製品番号: HY-168636p53 Activator 13 (compound 11) is a 6mA methyltransferase CamA inhibitor and a p53 activator. p53 Activator 13 intercalates into CamA-bound DNA via the minor groove, causing a conformational shift that moves the catalytic domain away from the DNA and elicits DNA damage response via p53 activation. p53 Activator 13 can be utilized in cancer research.
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MGMT-IN-1
0 Images製品番号: HY-180540MGMT-IN-1 (Compound 2) is a light-activated MGMT inhibitor. MGMT-IN-1 can effectively enhance the cytotoxicity of Temozolomide (TMZ) (HY-17364) only under light conditions, significantly increasing the DNA damage caused by TMZ. MGMT-IN-1 can be used for the study of chordoma.
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ZIKV-IN-2
0 Images製品番号: HY-151445CAS 番号: 910582-16-0ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV).
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DNMT3A-IN-4
0 Images製品番号: HY-184332DNMT3A-IN-4 is a DNMT3A inhibitor with an IC50 of 33.4 μM against human DNMT3A. DNMT3A-IN-4 inhibits the proliferation of colorectal cancer cells and can be used for the research of colorectal cancer.
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RG108 (GMP)
0 Images製品番号: HY-13642GCAS 番号: 48208-26-0RG108 (GMP) is RG108 (HY-13642) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.
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DNMT-IN-5
0 Images製品番号: HY-176230CAS 番号: 3126555-64-1DNMT-IN-5 is a stable and efficient DNA methyltransferase (DNMT) inhibitor with high stability and high activity with an IC50 of 0.78 nM. DNMT-IN-5 exhibits sub-micromolar DNMT3A inhibitory activity, upregulates the expression of DNMT-targeted genes, impairs cell proliferation, and triggers a critical cell cycle arrest. DNMT-IN-5 can be used for the study of p53-depleted colorectal cancer.
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Hedgehog IN-11
0 Images製品番号: HY-175299Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM).
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DNMT-IN-1
0 Images製品番号: HY-133030CAS 番号: 2396691-28-2DNMT-IN-1 is a potent DNMT inhibitor with an EC50 value of 3.2 µM. DNMT-IN-1 shows antiproliferative active.
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GSK3830052
0 Images製品番号: HY-183852CAS 番号: 2170141-06-5GSK3830052 is a selective DNA methyltransferase 1 (DNMT1) inhibitor. GSK3830052 can be used to study cancer, sickle cell disease, β-thalassemia, and other diseases associated with DNMT1 inhibition.
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Dihydro-5-azacytidine acetate
0 Images製品番号: HY-106689ACAS 番号: 2470972-18-8別名: DHAC acetate; NSC 264880 acetateDihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity.
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HaeIII Methyltransferase
0 Images製品番号: HY-E70211CAS 番号: 92228-40-5別名: HaeIIIHaeIII Methyltransferase (HaeIII) is a Methyltransferase which can bind covalently to DNA.
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DNMT-IN-4
0 Images製品番号: HY-172180DNMT-IN-4 (Compound 4d) is a DNMT inhibitor with an IC50 of 5.78 µM. DNMT-IN-4 can induce apoptosis and has anticancer activity.
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DNMT1 Degrader-1
0 ImagesDNMT1 Degrader-1 is a selective DNMT1 degrader with an IC50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1, thereby triggering UHRF1-mediated ubiquitination and degradation of DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia.
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2′-Deoxy-5-nitrocytidine
0 Images製品番号: HY-145950CAS 番号: 69100-02-32′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor extracted from patent CN108498529A. 2′-Deoxy-5-nitrocytidine can be used for the research of cancer.
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Dihydro-5-azacytidine
0 Images製品番号: HY-106689CAS 番号: 62488-57-7別名: DHAC; NSC 264880Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity.
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N-Acetyl-S-geranylgeranyl-L-cysteine
0 Images製品番号: HY-139137CAS 番号: 139332-94-8別名: AGGCN-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC50 of 45 nM.
