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Cat. No.: HY-151445

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ZIKV-IN-2

ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC₅₀ value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV).

For research use only. We do not sell to patients.

CAS No.: 910582-16-0
Formula: C₃₉H₄₂O₄
Molecular Weight:574.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ZIKV-IN-2 Chemical Structure

CAS No.: 910582-16-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 38.86 μM (MTase)^[1]

All DNA Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	6.79 μM Compound: 3d	Growth inhibition of human A549 cells after 72 hrs by SRB assay Growth inhibition of human A549 cells after 72 hrs by SRB assay	[PMID: 29097170]
HEK293	ED₅₀	4.68 μM Compound: 3d	Growth inhibition of human HEK293 cells after 72 hrs by SRB assay Growth inhibition of human HEK293 cells after 72 hrs by SRB assay	[PMID: 29097170]
HT-29	ED₅₀	8.38 μM Compound: 3d	Growth inhibition of human HT-29 cells after 72 hrs by SRB assay Growth inhibition of human HT-29 cells after 72 hrs by SRB assay	[PMID: 29097170]
HuCC-A1	ED₅₀	7.78 μM Compound: 3d	Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay	[PMID: 29097170]
KB	ED₅₀	4.94 μM Compound: 3d	Growth inhibition of human KB cells after 72 hrs by SRB assay Growth inhibition of human KB cells after 72 hrs by SRB assay	[PMID: 29097170]
MCF7	ED₅₀	4.86 μM Compound: 3d	Growth inhibition of human MCF7 cells after 72 hrs by SRB assay Growth inhibition of human MCF7 cells after 72 hrs by SRB assay	[PMID: 29097170]
P388	ED₅₀	3.87 μM Compound: 3d	Growth inhibition of mouse P388 cells after 72 hrs by SRB assay Growth inhibition of mouse P388 cells after 72 hrs by SRB assay	[PMID: 29097170]
Vero	CC₅₀	>200 μM Compound: 3a	Cytotoxicity against african green monkey Vero cells incubated for 96 hrs Cytotoxicity against african green monkey Vero cells incubated for 96 hrs	[PMID: 36055002]

In Vitro

ZIKV-IN-2 (compound 3a; 0.08-50 μM) inhibits the expression of ZIKV E protein with an EC₅₀ value of 6.17 μM and inhibits ZIKV replication and infection^[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Vero, Huh7 and A549 cells
Concentration:

0.08, 0.4, 2, 10, and 50 μM
Incubation Time:

96 hours
Result:

Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC₅₀>200 μM to all three cell lines.

Chemical Information

CAS No. 910582-16-0
Molecular Weight 574.75
Formula C₃₉H₄₂O₄
SMILES

[H][C@]12CCC([C@H]([C@@]1(CC[C@H]([C@]2(COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C)O)C)/C=C/C6=CCOC6=O)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ZIKV-IN-2

All DNA Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZIKV-IN-2 Related Classifications

HY-151445 Related Classifications