Discoidin Domain Receptor Inhibitor

ML786 is a potent and orally bioavailable Raf inhibitor, with IC₅₀s of 2.1, 4.2, and 2.5 nM for ^V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC₅₀=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 can be used for the research of cancers.

PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC₅₀ of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia.

DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC₅₀ values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity.

DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC₅₀ values​of 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research.

O,O-Dimethyl dithiophosphate-¹³C₂ ammonium is the ¹³C labeled isotope of O,O-Dimethyl dithiophosphate ammonium.