Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2752)
Related Products (2752)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Dankasterone A
0 ImagesCat. No.: HY-N17406CAS No.: 244303-77-3Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the Fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer.
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Oosporein (Standard)
0 ImagesOosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity.
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Hodgkinsine
0 ImagesCat. No.: HY-N12180ACAS No.: 18210-71-4Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities.
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1-Phenylsemicarbazide
0 ImagesCat. No.: HY-W280349CAS No.: 103-03-7Synonyms: 2-phenylhydrazinecarboxamide1-Phenylsemicarbazide is an antifungal agent. 1-Phenylsemicarbazide has the potential for preventing mold growth on industrial products.
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Antifungal agent 53
0 ImagesCat. No.: HY-153618CAS No.: 2422019-76-7Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.
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Miconazole-d2
0 ImagesCat. No.: HY-B0454S2CAS No.: 2140316-33-0Synonyms: R18134-d2Miconazole-d2 is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.
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Jelleine-II
0 ImagesCat. No.: HY-P11141Jelleine-II is a short chain antibacterial peptide derived from royal jelly, with broad-spectrum antibacterial activity. Jelleine-II has antibacterial activity against yeast, fungi, Gram positive bacteria, and Gram negative bacteria. Jelleine-II can be used in the study of infectious conditions.
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(±)-Emodin bianthrone
0 ImagesCat. No.: HY-N12276CAS No.: 61281-20-7(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities.
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SDH-IN-22
0 ImagesCat. No.: HY-172362SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC50 of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC50 of 0.5 mg/L.
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3',5,5'-Trichlorosalicylanilide
0 ImagesCat. No.: HY-W706466CAS No.: 106480-60-8Synonyms: TCSA3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.
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Heveadride
0 ImagesCat. No.: HY-N15653CAS No.: 39595-41-0Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM.
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Wormwood extract
0 ImagesCat. No.: HY-N20399Wormwood extract is an extract of Artemisia absinthium, which has antioxidant, antifungal, antibacterial, and anticancer effects.
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Antibacterial agent 131
0 ImagesAntibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production.
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LL-25
0 ImagesCat. No.: HY-P5729CAS No.: 740800-35-5LL-25 is a fragment of LL-37 (HY-P1222) but devoid of the immunomodulatory properties of LL-37. LL-25 has antifungal and candidacidal activity.
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Flubeneteram
0 ImagesCat. No.: HY-182278CAS No.: 1676101-39-5Flubeneteram is a succinate dehydrogenase inhibitor with an IC50 of 0.0484 μM. Flubeneteram disrupts succinate dehydrogenase activity. Flubeneteram demonstrates protective effects against Rhizoctonia solani and Sphaerotheca fuliginea in preclinical models. Flubeneteram can be used for research related to fungal infections.
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3-Nitrobenzoic acid-d4
0 ImagesCat. No.: HY-Y1313SCAS No.: 78399-78-7Synonyms: m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d43-Nitrobenzoic acid-d4 (m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d4) is the deuterium labeled 3-Nitrobenzoic acid (HY-Y1313). 3-Nitrobenzoic acid is an antioxidant and antibacterial agent that can kill bacteria and fungi. 3-Nitrobenzoic acid can be degraded or reduced by certain bacteria (such as Pseudomonas) and fungi (such as white rot fungi) into aldehydes and alcohols.
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Antifungal agent 62
0 ImagesCat. No.: HY-155658Antifungal agent 62 (Compound 3a) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 62 can be used for antiviral and fungicidal research.
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Antifungal agent 77
0 ImagesCat. No.: HY-155331CAS No.: 2863678-89-9Antifungal agent 77 (Compound 13h) is an antifungal agent. Antifungal agent 77 (500 μg/mL) also shows good insecticidal activity against Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis, and Spodoptera frugiperda with a death rate of 30%, 25%, 40%, and 25%. Antifungal agent 77 shows toxicity in zebrafish embryo with a LC50 of 2.43 μg/mL.
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Oleylphosphocholine
0 ImagesCat. No.: HY-114219CAS No.: 257925-44-3Oleylphosphocholine is an orally active antifungal and antiparasitic agent. Oleylphosphocholine is promising for research of invasive fungal diseases (e.g., aspergillosis) and visceral leishmaniasis.
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Antifungal agent 43
0 ImagesCat. No.: HY-151442CAS No.: 3033703-29-3Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines.
