Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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L-Diguluronic acid
0 ImagesCat. No.: HY-N7701CAS No.: 34044-54-7L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate. Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries.
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SDH-IN-27
0 ImagesCat. No.: HY-176413SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L). SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L). SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi.
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Triclopyricarb
0 ImagesCat. No.: HY-136356CAS No.: 902760-40-1Synonyms: SYP-7017Triclopyricarb (SYP-7017) is a strobilurin fungicide that can be used in crops disease control. Triclopyricarb inhibits mycelial growth with EC50 values ranged from 0.006 µg/mL to 0.047 µg/mL.
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Hb 98–114
0 ImagesCat. No.: HY-P5549Hb 98-114, the amino acids 98-114 of the alpha subunit of bovine hemoglobin, is an antimicrobial peptide. Hb 98-114 is active against several yeast and filamentous fungi (MIC: 2.1 μM-12.5 μM).
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Venturicidin B
0 ImagesCat. No.: HY-125637CAS No.: 33538-72-6Synonyms: Aabomycin A2Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex.
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Antifungal agent 56
0 ImagesCat. No.: HY-153621CAS No.: 2422019-82-5Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candida albicans strains with MIC values of 0.03-0.25 μg/mL.
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16,17-Dihydroheronamide C
0 ImagesCat. No.: HY-145407CAS No.: 2698333-36-516,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
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Sapindus saponaria linnaeus nutshell extract (70%)
0 ImagesCat. No.: HY-N20101Synonyms: Chinese soapberry fruit nutshell extract (70%); Sapindus mukorossi nutshell extract (70%); Sapindus abruptus nutshell extract (70%)Sapindus saponaria linnaeus nutshell extract (70%) (Chinese soapberry fruit nutshell extract (70%)) is a 70% extract of Sapindus saponaria fruit shells with antifungal activity.
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Antifungal agent 82
0 ImagesCat. No.: HY-157018Antifungal agent 82 (compound G34) is a antifungal agent. Antifungal agent 82 exhibits excellent in vitro antifungal activity against Valsa mali, with an EC50 of 0.57 μg/mL. Antifungal agent 82 also exhibits excellent in vivo protective effects against V. mali at 40 μg/mL.
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Mepronil
0 ImagesMepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
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Bactenecin
0 ImagesCat. No.: HY-P1508CAS No.: 116229-36-8Synonyms: Bactenecin, bovineBactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
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Antifungal agent 76
0 ImagesCat. No.: HY-156281CAS No.: 1615683-57-2Antifungal agent 76 (compound 23h) exhibits potent activities and a broad antifungal spectrum with low MICs of 0.25-16 μg/mL. Antifungal agent 76 might achieve its rapid fungicidal activity by disrupting the fungal cell membrane.
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Cn-AMP1
0 ImagesCat. No.: HY-P11177CAS No.: 1158169-22-2Cn-AMP1 is a disulfide-free plant peptide that can be isolated from green coconut water. Cn-AMP1 shows activity against multiple pathogenic bacteria, fungal pathogens and cancer cells. Cn-AMP1 is capable of up-regulating inflammatory-cytokine secretion by monocytes. Cn-AMP1 can be used for research on control bacterial infections and cancers.
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Undecanoic acid (Standard)
0 ImagesSynonyms: Undecanoate (Standard); Hendecanoic acid (Standard)Undecanoic acid (Standard) (Undecanoate (Standard)) is the analytical standard of Undecanoic acid (HY-W004282). This product is intended for research and analytical applications. Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
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Antituberculosis agent-6
0 ImagesCat. No.: HY-152136CAS No.: 2874263-72-4Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption.
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Y18501
0 ImagesCat. No.: HY-155131CAS No.: 2410627-32-4Y18501 is a oxysterol-binding protein (OSBPI) inhibitor with a similar structure to Oxathiapiprolin. Y18501 shows strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC50 ranging from 0.0005 to 0.0046 μg/mL. Y18501 shows excellent protective and curative activities against P. cubensis. Y18501 in combination with Chlorothalonil (HY-N6625) can significantly promote the inhibition of P. cubensis.
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Frenolicin B
0 ImagesCat. No.: HY-W671129CAS No.: 68930-68-7Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC50 of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits Peroxiredoxin 1 via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria.
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1-Methoxyberberine chloride
0 ImagesCat. No.: HY-N9711CAS No.: 29133-52-61-Methoxyberberine chloride is a plant alkaloid that can be found in Corydalis longipes. 1-Methoxyberberine chloride exhibits antifungal effects.
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ent-Heronamide C
0 ImagesCat. No.: HY-145407Aent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
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Antifungal agent 92
0 ImagesCat. No.: HY-163337CAS No.: 3020687-94-6Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III.
