GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (795)
Related Products (795)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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Bretazenil (Standard)
0 ImagesCat. No.: HY-105056RCAS No.: 84379-13-5Synonyms: Ro 16-6028 (Standard)Bretazenil (Standard) is the analytical standard of Bretazenil (HY-105056). This product is intended for research and analytical applications. Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABAA) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC50 (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC50 of 10 nM for recombinant α1β1γ2. Anticonvulsant effects.
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Imagabalin
0 ImagesCat. No.: HY-14843CAS No.: 610300-07-7Synonyms: PD-0332334free baseImagabalin (PD-0332334 free base) is an active compound with activity for studying neurological diseases. The synthesis of imagabalin involves the reaction of 3-methylvaleric acid and Meldrum acid. During the synthesis of imagabalin, an acyl chloride intermediate species, 3-methylvaleryl chloride, was revealed for the first time. The synthesis of imagabalin also provided new information about the reaction mechanism, indicating that 3-methylvaleric anhydride is an important intermediate.
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Carboetomidate
0 ImagesCat. No.: HY-121102CAS No.: 1257067-10-9Carboetomidate is a pyrrole derivative analogous to the sedative-hypnotic drug Etomidate, which induces general anesthesia while avoiding the inhibition of adrenal steroid synthesis. Carboetomidate enhances GABAA receptor function via β2/β3 subunits, inhibits neuronal nicotinic acetylcholine receptors (nAChR) and 5-HT3A receptors, and increases plasma IL-10 levels during endotoxemia. Carboetomidate is applicable to research related to sepsis and sleep disorders.
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Saripidem
0 ImagesCat. No.: HY-106875CAS No.: 103844-86-6Saripidem is a non-selective ligand for ω modulatory sites of GABA receptor.
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Suritozole
0 ImagesCat. No.: HY-114706CAS No.: 110623-33-1Synonyms: MDL-26479Suritozole (MGL-26479) is a cognitive enhancer that acts as a partial inverse agonist of benzodiazepine receptor sites on GABAA ion channel complexes. Suritozole can be used in the study of neurodegenerative diseases.
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CL 218872 (Standard)
0 ImagesCat. No.: HY-103505RCAS No.: 66548-69-4CL 218872 (Standard) is the analytical standard of CL 218872 (HY-103505). This product is intended for research and analytical applications. CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy.
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GMQ
0 ImagesGMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.
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Isoguvacine hydrochloride (Standard)
0 ImagesIsoguvacine (hydrochloride) (Standard) is the analytical standard of Isoguvacine (hydrochloride) (HY-100810). This product is intended for research and analytical applications. Isoguvacine hydrochloride is a GABA receptor agonist.
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GABAB receptor antagonist 3
0 ImagesCat. No.: HY-160105CAS No.: 160415-40-7GABAB receptor antagonist 3 (example 3) is a antagonist of GABAB receptor.
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DS1
0 ImagesCat. No.: HY-136942CAS No.: 372497-52-4DS1 is a potent GABAA agonist. DS1 increases the activity of serum response element (SRE) and cAMP response element (CRE) promoters. DS1 induces luteinizing hormone beta (LHbeta) and follicle-stimulating hormone beta (FSHbeta) promoter activity.
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Tuclazepam
0 ImagesCat. No.: HY-167658CAS No.: 51037-88-8Synonyms: KC 1956Tuclazepam (KC 1956) is a derivative of benzodiazepines that has anti-anxiety and sedative effects.
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CGP47656
0 ImagesCat. No.: HY-129710CAS No.: 133345-73-0
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Emamectin-d3
0 ImagesCat. No.: HY-W765182Emamectin-d3 is the deuterium labeled Emamectin. Emamectin is a macrocyclic lactone insecticide. Emamectin acts as agonist for GABA-gated chloride channels.
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SCS (Standard)
0 ImagesCat. No.: HY-103528RCAS No.: 3232-36-8Synonyms: Salicylidene salicylhydrazide (Standard)SCS (Standard) is the analytical standard of SCS (HY-103528). This product is intended for research and analytical applications. SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions.
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(R)-Baclofen hydrochloride
0 ImagesSynonyms: Arbaclofen hydrochloride; STX 209 hydrochloride(R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist.
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Phenibut (Standard)
0 ImagesCat. No.: HY-108403RCAS No.: 1078-21-3Synonyms: β-Phenyl-GABA (Standard); 4-Amino-3-phenylbutanoic acid (Standard)Phenibut (Standard) is the analytical standard of Phenibut (HY-108403). This product is intended for research and analytical applications. Phenibut (β-Phenyl-GABA) is a GABA-B agonist. Phenibut acts as a GABA-mimetic, primarily at GABAB receptors. Phenibut has anxiolytic and nootropic (cognition enhancing) effects.
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Valnoctamide-d5
0 ImagesCat. No.: HY-121877SCAS No.: 1190015-82-7Valnoctamide-d5 is the deuterium labeled Valnoctamide. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors.
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ETK-II-83
0 ImagesCat. No.: HY-189453ETK-II-83 is an orally effective and blood-brain barrier-penetrant ligand for the benzodiazepine site of the GABAA receptor. ETK-II-83 displaces 3H-flunitrazepam from rat brain GABAA receptors and selectively binds to the α5-containing subtype. ETK-II-83 can be used for anxiety research.
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α-Thujone (Standard)
0 ImagesCat. No.: HY-121618RCAS No.: 546-80-5α-Thujone (Standard) is the analytical standard of α-Thujone. This product is intended for research and analytical applications. α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier.
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Cirsimaritin (Standard)
0 ImagesCirsimaritin (Standard) is the analytical standard of Cirsimaritin (HY-N6648). This product is intended for research and analytical applications. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.
