Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (688)
Related Products (688)
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Antibodies (3)
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α-Glucosidase-IN-112
0 ImagesCat. No.: HY-181353α-Glucosidase-IN-112 is an α-glucosidase inhibitor with an IC50 of 2.03 μM and a Ki of 0.44 μM. α-Glucosidase-IN-112 exerts antioxidant effects by scavenging ABTS+ free radicals. α-Glucosidase-IN-112 exerts antiproliferative effects by inhibiting the proliferation of bladder cancer cells. α-Glucosidase-IN-112 can be used in research related to type 2 diabetes and bladder cancer.
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Dextranase, Penicillium sp.
0 ImagesCat. No.: HY-P2840ADextranase, Penicillium sp. belongs to glycoside hydrolase family 49. It catalyzes the hydrolysis of α-1,6-glycosidic linkages in dextran via a single-displacement reaction, ultimately releasing shorter isomaltooligosaccharides. Dextranase, Penicillium sp. reduces the molecular size of dextran, inhibits the formation of insoluble dextran and dental plaque, and decreases the viscosity of dextran-contaminated sugar juice. Dextranase, Penicillium sp. can be used in relevant research in fields such as chemical production, including beer manufacturing, feed additives, and toothpaste formulations.
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α-Glucosidase-IN-120
0 ImagesCat. No.: HY-187171α-Glucosidase-IN-120 is an α-glucosidase (α-glucosidase) inhibitor that effectively inhibits α-glucosidase from Saccharomyces cerevisiae (IC50 = 12.01 μM, Ki = 21 μM). α-Glucosidase-IN-120 shows higher selectivity for α-glucosidase than for α-amylase and does not inhibit α-amylase activity. α-Glucosidase-IN-120 exhibits no significant cytotoxicity. α-Glucosidase-IN-120 can be used in the research of type 2 diabetes.
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HPA-IN-3
0 ImagesCat. No.: HY-184684HPA-IN-3 (compound 5) is a heparanase (HPA) inhibitor with an IC50 of 11.27 μM against human targets. HPA-IN-3 binds to the active site of HPA, and its structural features enhance binding stability and affinity. HPA-IN-3 reduces the levels of proinflammatory cytokines. HPA-IN-3 maintains organ morphology. HPA-IN-3 improves the survival rate of mice with sepsis induced by cecal ligation and puncture. HPA-IN-3 can be used in studies related to sepsis.
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Anti-Heparanase Antibody
0 ImagesCat. No.: HY-P992234
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Gambogin
0 ImagesCat. No.: HY-182460CAS No.: 173792-67-1Gambogin is an α-glucosidase inhibitor, found in the resin and dry latex of Garcinia hanburyi. Gambogin exists as an inseparable diastereomeric pair of C-2 epimers (8a and 8b), with 8a having an α-glucosidase inhibitory IC50 of 209.2 μM and 8b showing α-glucosidase inhibitory IC50 > 300 μM. Gambogin can be used for the research of type 2 diabetes and cervical cancer.
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2,3-Indolobetulin
0 ImagesCat. No.: HY-138992CAS No.: 2365493-59-82,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin. 2,3-Indolobetulin can be used in the synthesis of α-glucosidase inhibitors.
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α-Glucosidase-IN-20
0 ImagesCat. No.: HY-151144CAS No.: 420809-56-9α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity.
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Glycyrrhisoflavone (Standard)
0 ImagesCat. No.: HY-N3962RCAS No.: 116709-70-7Glycyrrhisoflavone (Standard) is the analytical standard of Glycyrrhisoflavone. This product is intended for research and analytical applications. Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase.
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β-Galactosidase Mutein, E. coli
0 ImagesCat. No.: HY-E70890β-Galactosidase Mutein, E. coli is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.
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β-L-Rhamnosidase
0 ImagesCat. No.: HY-E71307β-L-Rhamnosidase (EC 3.2.1.43) belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O-and S-glycosyl compounds.
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Cyclo (D-Pro-L-Val)
0 ImagesCat. No.: HY-N14562CAS No.: 156617-55-9Cyclo (D-Pro-L-Val) can inhibit β-glycosidase enzyme activity with IC50 of 75 μg/mL. Cyclo (D-Pro-L-Val) has no or only weak inhibitory effect on other glycosidases.
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Gitogenin (Standard)
0 ImagesGitogenin (Standard) is the analytical standard of Gitogenin. This product is intended for research and analytical applications. Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.
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3-O-trans-p-Coumaroyltormentic acid
0 ImagesCat. No.: HY-N1864CAS No.: 121064-78-63-O-trans-p-Coumaroyltormentic acid is a triterpene having no cytotoxic activity. However, 3-O-cris-p-Coumaroyltormentic acid is a cytotoxic triterpene, can be isolated from the methanol extract of Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). 3-O-trans-p-Coumaroyltormentic acid is an inhibitor of alpha-glucosidase and Indoleamine 2,3-Dioxygenase (IDO), and it has anti-inflammatory activity.
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GCase modulator-2
0 ImagesGCase modulator-2 (Compound 1) is a glucocerebrosidase (GCase) modulator. GCase modulator-2 can be used in the research of Gaucher's disease and Parkinson's disease.
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(+)-Cembrene A
0 ImagesCat. No.: HY-N10426CAS No.: 72691-72-6(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC50 of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells.
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Zaluzanin C
0 ImagesCat. No.: HY-N15415CAS No.: 16838-87-2Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity.
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Afegostat tartrate
0 ImagesCat. No.: HY-14829BCAS No.: 919364-56-0Synonyms: AT 2101; D-Isofagomine tartrate; Isofagomine tartrateAfegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
