Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (697)
Related Products (697)
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Antibodies (3)
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Cyclo (D-Pro-L-Val)
0 ImagesCat. No.: HY-N14562CAS No.: 156617-55-9Cyclo (D-Pro-L-Val) can inhibit β-glycosidase enzyme activity with IC50 of 75 μg/mL. Cyclo (D-Pro-L-Val) has no or only weak inhibitory effect on other glycosidases.
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Gitogenin (Standard)
0 ImagesGitogenin (Standard) is the analytical standard of Gitogenin. This product is intended for research and analytical applications. Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.
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3-O-trans-p-Coumaroyltormentic acid
0 ImagesCat. No.: HY-N1864CAS No.: 121064-78-63-O-trans-p-Coumaroyltormentic acid is a triterpene having no cytotoxic activity. However, 3-O-cris-p-Coumaroyltormentic acid is a cytotoxic triterpene, can be isolated from the methanol extract of Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). 3-O-trans-p-Coumaroyltormentic acid is an inhibitor of alpha-glucosidase and Indoleamine 2,3-Dioxygenase (IDO), and it has anti-inflammatory activity.
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GCase modulator-2
0 ImagesGCase modulator-2 (Compound 1) is a glucocerebrosidase (GCase) modulator. GCase modulator-2 can be used in the research of Gaucher's disease and Parkinson's disease.
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(+)-Cembrene A
0 ImagesCat. No.: HY-N10426CAS No.: 72691-72-6(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC50 of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells.
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Zaluzanin C
0 ImagesCat. No.: HY-N15415CAS No.: 16838-87-2Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity.
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Afegostat tartrate
0 ImagesCat. No.: HY-14829BCAS No.: 919364-56-0Synonyms: AT 2101; D-Isofagomine tartrate; Isofagomine tartrateAfegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
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MPO-IN-6
0 ImagesCat. No.: HY-163332MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC50s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent.
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Maltose monohydrate (Standard)
0 ImagesMaltose monohydrate (Standard) is the analytical standard of Maltose monohydrate. This product is intended for research and analytical applications. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.
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Kaempferol 3-O-gentiobioside (Standard)
0 ImagesCat. No.: HY-N1510RCAS No.: 22149-35-5Kaempferol 3-O-gentiobioside (Standard) is the analytical standard of Kaempferol 3-O-gentiobioside. This product is intended for research and analytical applications. Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC50 of 50.0 μM.
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5-Amino-1-(pyridin-3-yl)-1h-imidazole-4-carboxamide
0 ImagesCat. No.: HY-W907070CAS No.: 1798713-75-35-Amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide is a riboswitch ligand. 5-Amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide effectively activates riboswitches during in vitro transcription and induces β-galactosidase expression.
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9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one
0 ImagesCat. No.: HY-N9075CAS No.: 204134-70-39-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L).
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erythro-Guaiacylglycerol β-coniferyl ether
0 ImagesCat. No.: HY-N3864CAS No.: 890317-92-7Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits α-Glycosidase activity with EC50 value of 18.71 μM.
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OGT 2115 (Standard)
0 ImagesCat. No.: HY-100898RCAS No.: 853929-59-6OGT 2115 (Standard) is the analytical standard of OGT 2115 (HY-100898). This product is intended for research and analytical applications. OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity.
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Panosialin wA
0 ImagesCat. No.: HY-N14907CAS No.: 792162-72-2Panosialin wA can inhibit α,β-glucosidase and mannose glycosidase. Panosialin wA does not inhibit the influenza virus, but it has weak anti-microbial effect.
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Pinoresinol 4-O-β-D-glucopyranoside (Standard)
0 ImagesCat. No.: HY-N2168RCAS No.: 69251-96-3Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects.
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Brevifolincarboxylic acid (Standard)
0 ImagesCat. No.: HY-N4095RCAS No.: 18490-95-4Brevifolincarboxylic acid (Standard) is the analytical standard of Brevifolincarboxylic acid (HY-N4095). This product is intended for research and analytical applications. Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC50 value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases.
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N-Methyltetrachlorophthalimide
0 ImagesCat. No.: HY-W130043CAS No.: 14737-80-5N-Methyltetrachlorophthalimide (Compound 4) is an inhibitor of α-glucosidase with an IC50 of 22.1 μM. N-Methyltetrachlorophthalimide can be used in anti-diabetic and anti-viral research.
