1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
    Neuronal Signaling
  3. Histamine Receptor
  4. H4 Receptor Isoform
  5. H4 Receptor Antagonist

H4 Receptor Antagonist

H4 Receptor Antagonists (9):

Cat. No. Product Name Effect Purity
  • HY-13508
    JNJ-7777120
    Antagonist 99.97%
    JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM).
  • HY-101189
    JNJ-39758979
    Antagonist ≥98.0%
    JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively.
  • HY-111501
    H4R antagonist 1
    Antagonist 98.37%
    H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM.
  • HY-101188
    INCB38579
    Antagonist 99.97%
    INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM).
  • HY-107558
    JNJ10191584 maleate
    Antagonist
    JNJ10191584 (VUF6002) maleate (compound 40) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM.
  • HY-123532
    JNJ10191584
    Antagonist
    JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM.
  • HY-101189B
    JNJ-39758979 dihydrochloride
    Antagonist
    JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H4 receptor antagonist, with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively.
  • HY-147276
    Izuforant
    Antagonist
    Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R.
  • HY-16756
    Toreforant
    Antagonist 99.82%
    Toreforant is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM.