2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. IRE1
  5. IRE1 Degrader

IRE1 Degrader

IRE1 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-180780
    G1167
    		Degrader
    G1167 is an IRE1 ligand, which can be used for the synthesis of PROTACs, such as G6374 (HY-180787).
  • HY-180787
    G6374
    		Degrader
    G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation.