Isotope-Labeled Compounds
Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.
MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.
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Isotope-Labeled Compounds Produits associés (11128)
Produits associés (11128)
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D-Lyxose-d
0 ImagesCat. No.: HY-128753S6CAS No.: 288846-88-8D-Lyxose-d is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose.
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2'-Deoxyadenosine-15N1
0 ImagesCat. No.: HY-W745905CAS No.: 106568-85-82'-Deoxyadenosine-15N1 is the 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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Perfluoro-n-tetradecanoic acid-13C2
0 ImagesCat. No.: HY-W751343CAS No.: 2708218-82-8Synonyms: PFTeDA-13C2Perfluoro-n-tetradecanoic acid-13C2 (PFTeDA-13C2) is the 13C-labeled Perfluoro-n-tetradecanoic acid.
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3-Methylcrotonylglycine-d2
0 ImagesCat. No.: HY-113232SCAS No.: 1276197-31-93-Methylcrotonylglycine-d2 is the deuterated-labeled 3-Methylcrotonylglycine (HY-113232). 3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na+, K+-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency.
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Lapatinib-13C215N
0 ImagesCat. No.: HY-W777297CAS No.: 1246819-08-8Lapatinib-13C2,15N Ditosylate is the 13C- and 15N-labeled Lapatinib ditosylate (HY-50898A). Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
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Dansyl acid-d6
0 ImagesCat. No.: HY-W268193SCAS No.: 1329836-02-3Dansyl acid-d6 is the deuterium labeled Propan-2-amine hydrochloride.
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Duostatin 5-13C,d3
0 ImagesCat. No.: HY-145149SDuostatin 5-13C,d3 is the 13C-labeled Duostatin 5 (HY-145149). Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
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Nilvadipine-d4
0 ImagesCat. No.: HY-14284SCAS No.: 2928067-26-7Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
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2'-Deoxyuridine-2′-13C
0 ImagesCat. No.: HY-D0186S1CAS No.: 478510-87-12'-Deoxyuridine-2′-13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]-
Didecyl phthalate-d4
0 ImagesCat. No.: HY-W010875SCAS No.: 1276197-18-2Didecyl phthalate-d4 is the deuterium labeled Didecyl phthalate.
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Empagliflozin-d8
0 ImagesCat. No.: HY-166652SCAS No.: 2714418-84-3Empagliflozin-d8 is the deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
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Erucic acid-d18-1
0 ImagesCat. No.: HY-N7109S3Erucic acid-d18-1 is the deuterium labeled Erucic acid (HY-N7109). Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia.
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6PPD-Quinone methyl ester-d5
0 ImagesCat. No.: HY-W754406Synonyms: Methyl carboxylate 6ppd-quinone-d56PPD-Quinone methyl ester-d5 (Methyl carboxylate 6ppd-quinone-d5) is the deuterium labeled 6PPD-Quinone methyl ester.
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Sulfaguanidine-d4
0 ImagesCat. No.: HY-B1267SPureté: 98.0%Sulfaguanidine-d4 is the deuterium labeled Sulfaguanidine. Sulfaguanidine, belongs to the class of sulfonamide agent, is an orally active antibiotic. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.
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11-([1,1':3',1''-Terphenyl]-3-yl)-11,12-dihydroindolo[2,3-a]carbazole-d22
![11-([1,1':3',1''-Terphenyl]-3-yl)-11,12-dihydroindolo[2,3-a]carbazole-d22](https://file.medchemexpress.com/product_pic/hy-184762s.gif "Click to View 11-([1,1':3',1''-Terphenyl]-3-yl)-11,12-dihydroindolo[2,3-a]carbazole-d22 Product Detail")
0 ImagesCat. No.: HY-184762S11-([1,1':3',1''-Terphenyl]-3-yl)-11,12-dihydroindolo[2,3-a]carbazole-d22 is the deuterium labeled 11-([1,1':3',1''-Terphenyl]-3-yl)-11,12-dihydroindolo[2,3-a]carbazole.
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1,2-Dihexanoyl-sn-glycero-3-phosphocholine-d31
0 ImagesCat. No.: HY-W127457S31,2-Dihexanoyl-sn-glycero-3-phosphocholine-d31 is the deuterium labeled 1,2-Dihexanoyl-sn-glycero-3-phosphocholine. 1,2-Dihexanoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine. It can play a role as a surfactant and is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.
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Acipimox-d4
0 ImagesCat. No.: HY-B0283SCAS No.: 1246816-28-3Synonyms: K-9321-d4Acipimox-d4 is the deuterium labeled Acipimox. Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox acutely inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.
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Famotidine-13C3
0 ImagesCat. No.: HY-W777002CAS No.: 1185241-48-8Synonyms: MK-208-13C3Famotidine-13C3 (MK-208-13C3) is the 13C3-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
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L-Thyroxine-13C9,15N
0 ImagesCat. No.: HY-18341S3CAS No.: 1431868-11-9
