Leukotriene Receptor
Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.
Leukotriene Receptor Isoform Specific Products
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Leukotriene Receptor Inhibitors
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Leukotriene Receptor Agonists
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Leukotriene Receptor Antagonists
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Leukotriene Receptor Activators
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Leukotriene Receptor Control
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Leukotriene Receptor Substrate
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Leukotriene Receptor Related Products (229)
Related Products (229)
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Antibodies (1)
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Leukotriene Receptor Isoform Comparison
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Zafirlukast metabolite M1
0 ImagesCat. No.: HY-131471CAS No.: 219583-10-5Zafirlukast metabolite M1 (compound 15) is an inhibitor of allergic lung diseases such as asthma and can antagonize the activity of leukotrienes.
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LTB4 antagonist 2
0 ImagesCat. No.: HY-149083CAS No.: 2929239-85-8LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity. LTB4 antagonist 2 shows good affinity for the LTB4 receptor with IC50 of 439 nM.
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Montelukast sodium (Standard)
0 ImagesSynonyms: MK0476 (Standard)Montelukast (sodium) (Standard) is the analytical standard of Montelukast (sodium). This product is intended for research and analytical applications. Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research.
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CP-85958
0 ImagesCat. No.: HY-19241CAS No.: 134002-60-1CP-85958 is a specific leukotriene D4 (LTD4) receptor antagonist. CP-85958 can be used in the research of inflammatory diseases such as asthma.
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ZM 230487
0 ImagesCat. No.: HY-120095CAS No.: 155944-23-3Synonyms: ICI-230487ZM 230487 (ICI-230487) is an orally active, selective, non-redox 5-lipoxygenase (5-LO) inhibitor. ZM 230487 potently inhibits antigen-induced LTD4 release (IC50 ≈ 0.2 µM), but does not affect the release of TXB2 and histamine. ZM 230487 specifically blocks eosinophil accumulation and partial bronchoconstriction in guinea pig models. ZM 230487 can be used in studies related to allergic inflammation.
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ONO-RS-347
0 ImagesCat. No.: HY-113693CAS No.: 103176-67-6ONO-RS-347 is an orally active and potent antagonist of leukotriene C4 and D4. ONO-RS-347 inhibits LTD4-induced bronchoconstriction in guinea pigs. ONO-RS-347 is promising for research of allergic asthma and other immediate hypersensitivty diseases.
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LTB4 antagonist 3
0 ImagesCat. No.: HY-149084CAS No.: 2929239-87-0LTB4 antagonist 3 (compound 24e) is a leukotriene B4 (LTB4) antagonist with an IC50 value of 477 nM. LTB4 antagonist 3 has anti-inflammatory activity.
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(5S,6R)-DiHETEs
0 ImagesCat. No.: HY-130138BCAS No.: 129263-59-8Synonyms: (5S,6R)-(11E)-DiHETE(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists.
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YM-17690
0 ImagesCat. No.: HY-100724CAS No.: 108806-41-3YM-17690 is a LTD4 and LTE4 agonist, with a pKi value of 9.28 for [3H]LTD4. It induces dose-dependent contractions in guinea pig ileum, lung parenchyma, and trachea, with EC50 values of 16, 3.9, and 22 nM, respectively. YM-17690 can be used in research related to asthma and inflammation.
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(Rac)-LY-2300559
0 ImagesCat. No.: HY-111197ACAS No.: 889115-58-6(Rac)-LY-2300559 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGlu2) and an antagonist of cysteinyl leukotriene 1 (CysLT1) receptor, with both EC50 and IC50 values less than 12.5 μM. (Rac)-LY-2300559 enhances glutamate-induced mGlu2 receptor signaling while exerting antagonistic activity against the CysLT1 receptor. (Rac)-LY-2300559 can be used in migraine-related research.
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FK-664
0 ImagesCat. No.: HY-19020CAS No.: 94936-90-0FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure.
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RG 14893
0 ImagesCat. No.: HY-112736CAS No.: 141835-49-6RG 14893 is a high affinity, competitive, orally active leukotriene B4 receptor antagonist.
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Ablukast
0 ImagesSynonyms: Ro 23-3544Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction. Ablukast is LTD4 receptor antagonist.
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Bay-X-7195
0 ImagesCat. No.: HY-19161CAS No.: 143538-27-6Bay-X-7195 is a CYS leukotriene 1 receptor (CYS LT1) antagonist. Bay-X-7195 shows an antagonistic action to LTD4-induced bronchoconstriction in vitro and in vivo. Bay-X-7195 can be used foe the study of allergic and asthmatic.
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SM-15178
0 ImagesCat. No.: HY-180411CAS No.: 146461-98-5SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma.
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SC-53228
0 ImagesCat. No.: HY-112740CAS No.: 153633-01-3SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis.
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Pranlukast-d4
0 ImagesCat. No.: HY-B0290S1CAS No.: 2713172-43-9Synonyms: ONO-1078-d4Pranlukast-d4 is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.
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L-691678
0 ImagesCat. No.: HY-118979CAS No.: 144210-49-1
