Bay-X-7195
Bay-X-7195 is a CYS leukotriene 1 receptor (CYS LT1) antagonist. Bay-X-7195 shows an antagonistic action to LTD4-induced bronchoconstriction in vitro and in vivo. Bay-X-7195 can be used foe the study of allergic and asthmatic.
For research use only. We do not sell to patients.
- CAS No.: 143538-27-6
- Formula: C30H32O6S
- Molecular Weight:520.64
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Leukotriene Receptor Isoforms
More
Biological Activity
In in vitro experiments, Bay-X-7195 inhibits LTD4-induced contraction of isolated guinea pig tracheal muscle (pA2 = 8.03)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In mice, aeroantigen-induced airway inflammation are clearly inhibited by Bay-X-7195[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 143538-27-6
-
Molecular Weight 520.64
-
Formula C30H32O6S
-
SMILES
O=C(O)C1=CC=C(S[C@@H](CCC(O)=O)/C=C\CC2=CC=C(OCCCCOC3=CC=CC=C3)C=C2)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Boulet LP, et al. Inhibitory effects of BAY x 7195, a CYS leukotriene 1 receptor antagonist, on allergen-induced asthmatic responses. Ann Allergy Asthma Immunol. 1997 Aug;79(2):155-61. [Content Brief]
[2]. Tanaka H, et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. Prostaglandins. 1995 Nov-Dec;50(5-6):269-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bay-X-7195 Related Classifications
HY-19161 Related Classifications
Powered by Bioz