Leukotriene Receptor
Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.
Leukotriene Receptor Isoform Specific Products
All Product Categories
-
Leukotriene Receptor Inhibitors
(62)
View all products
-
Leukotriene Receptor Agonists
(10)
View all products
-
Leukotriene Receptor Antagonists
(127)
View all products
-
Leukotriene Receptor Activators
(2)
View all products
-
Leukotriene Receptor Control
(1)
View all products
-
Leukotriene Receptor Substrate
(1)
View all products
-
Leukotriene Receptor Related Products (225)
Related Products (225)
-
Antibodies (1)
-
Leukotriene Receptor Isoform Comparison
-
(rac)-ONO 2050297
0 ImagesCat. No.: HY-117943CAS No.: 847655-51-0(rac)-ONO 2050297 is a benzoxazole derivative and a potent biCysLT1/CysLT2 antagonist with IC50 values are 17 nM and 0.87 nM respectively.
-
E 6080
0 ImagesCat. No.: HY-180363CAS No.: 120164-49-0E 6080 is an orally active and selective 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 0.2 μM in rat basophilic leukemia cell. E 6080 shows potent inhibitory effects on the release of leukotrienes. E 6080 inhibits the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs. E 6080 can be used for the study of asthma.
-
Sulukast
0 ImagesCat. No.: HY-127115CAS No.: 98116-53-1Synonyms: LY 170680Sulukast (LY 170680) is a selective leukotriene D4 (LTD4) antagonist. Sulukast exerts an effective antagonistic effect on bronchoconstriction induced by LTD4. Sulukast can be used in the research of diseases such as asthma.
-
12-epi-LTB4
0 ImagesCat. No.: HY-137350CAS No.: 83709-73-312-epi-LTB4 is an agonist for BLT1 and BLT2. 12-epi LTB4 exhibits a partial agonistic activity against mBLT1 and mBLT2, and induces phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes.
-
Leukotriene B4 ethanolamide
0 ImagesCat. No.: HY-131651CAS No.: 877459-63-7Synonyms: LTB4 ethanolamideLeukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation.
-
Triptinin B
0 ImagesCat. No.: HY-N8892CAS No.: 189389-05-7Triptinin B (compound 2) is a LTD4 antagonist that can be isolated from Tripterygium wilfordii.
-
SCH 40120
0 ImagesCat. No.: HY-124099CAS No.: 110545-79-4SCH 40120 is a potent leukotriene inhibitor with antiinflammatory effects. SCH 40120 suppresses T cell proliferative responses, antigen-specific and poly-clonally-induced in vitro antibody responses. SCH 40120 suppresses an edematous response and inhibits the recruitment of circulating neutrophils into sites of inflammation. SCH 40120 is proming for rasearch of anti-psoriatic agents.
-
JNJ-40929837 succinate
0 ImagesCat. No.: HY-156960ACAS No.: 1191044-47-9JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research.
-
γ-Linolenic acid ethyl ester-d5
0 ImagesCat. No.: HY-W744842Synonyms: Ethyl γ-linolenate-d5γ-Linolenic acid ethyl ester-d5 (Ethyl γ-linolenate-d5) is the deuterium labeled γ-Linolenic acid ethyl ester (HY-108396). γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B4 receptor 4 (LTB4) antagonist.
-
LTD4 antagonist 3
0 ImagesCat. No.: HY-19178CAS No.: 149437-51-4Synonyms: FK011 hydrochlorideLTD4 antagonist 3 (FK011 hydrochloride) is a LTD4 antagonist. LTD4 antagonist 3 has agonistic activity for PPAR-γ, with a fold-increase of 1.50 at 1 μM and 2.35 at 10 μM. LTD4 antagonist 3 can be used of development of non-steroidal anti-inflammatory drugs (NSAIDs).
-
SC-39070
0 ImagesCat. No.: HY-113727CAS No.: 98193-06-7SC-39070 is a LTD4 receptor antagonist. SC-39070 blocks the contractile effect of LTD4 on guinea pig trachea.
-
AZD6642
0 ImagesCat. No.: HY-12996CAS No.: 1643809-54-4AZD6642 is a 5-lipoxygenase activating protein (FLAP) inhibitor. AZD6642 can effectively inhibit the production of LTB4. AZD6642 exhibits high oral bioavailability in rats and dogs. AZD6642 can be used in the research of inflammatory diseases.
-
SC-45694 lithium
0 ImagesCat. No.: HY-123014ACAS No.: 1927834-56-7SC-45694 (lithium) is an analog of LTB4. SC-45694 (lithium) exhibits an agonist activity against LTB4 for chemotaxis and an antagonist activity against LTB4-induced degranulation. SC-45694 (lithium) stimulates neutrophil chemotaxis.
-
ST026567
0 ImagesCat. No.: HY-W511185CAS No.: 5067-25-4ST026567 is a potent mast cell activator. ST026567 induces the secretion of PGD2, LTC4 from cells. ST026567 exhibits degranulation potency.
-
(R)-Ontazolast
0 ImagesCat. No.: HY-105176ACAS No.: 149106-77-4Synonyms: (R)-BIRM-270(R)-Ontazolast ((R)-BIRM-270) is a potent inhibitor of leukotriene biosynthesis, effectively blocking the release of arachidonic acid and demonstrating an impressive IC50 value of 0.001 microM in human polymorphonuclear leukocytes.
-
Moxilubant hydrochloride
0 ImagesCat. No.: HY-106929BCAS No.: 146957-32-6Synonyms: CGS 25019C hydrochlorideMoxilubant (CGS 25019C) hydrochloride is an orally active BLT1 antagonist. Moxilubant hydrochloride inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant hydrochloride blocks LTB4-induced neutrophil functions. Moxilubant hydrochloride inhibits ear edema and neutrophil infiltration in mice. Moxilubant hydrochloride can be used in research related to chronic obstructive pulmonary disease.
-
Zafirlukast metabolite M1
0 ImagesCat. No.: HY-131471CAS No.: 219583-10-5Zafirlukast metabolite M1 (compound 15) is an inhibitor of allergic lung diseases such as asthma and can antagonize the activity of leukotrienes.
-
LTB4 antagonist 2
0 ImagesCat. No.: HY-149083CAS No.: 2929239-85-8LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity. LTB4 antagonist 2 shows good affinity for the LTB4 receptor with IC50 of 439 nM.
-
Montelukast sodium (Standard)
0 ImagesSynonyms: MK0476 (Standard)Montelukast (sodium) (Standard) is the analytical standard of Montelukast (sodium). This product is intended for research and analytical applications. Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research.
