Leukotriene B4 ethanolamide
Leukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation.
For research use only. We do not sell to patients.
- CAS No.: 877459-63-7
- Formula: C22H37NO4
- Molecular Weight:379.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human Endogenous Metabolite |
Leukotriene B4 ethanolamide suppresses the contractile action of LTB 4 in guinea-pig isolated lung parenchyma with Kb of 7.28 nM[1].
Leukotriene B4 ethanolamide (1 μM) acts as a partial agonist for BLT receptor in cell PMN, induces PMN migration with pEC50 of 7[2].
Leukotriene B4 ethanolamide (1 μM) stimulates Ca2+ release in rat TRPV1-expressing CHO cells with pEC50 of 7.28[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PMN
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Concentration:1 μM
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Incubation Time:
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Result:Induced migration of neutrophils.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Melanoma tumor in C57BL/6 mouse models[2]
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Dosage:100 nM/mouse
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Administration:s.c., once a day for 5 days
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Result:Inhibited melanoma tumor growth in mice coinjected with apoptotic Tm1 melanoma cells and a subtumorigenic dose of Tm1.
Chemical Information
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CAS No. 877459-63-7
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Molecular Weight 379.53
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Formula C22H37NO4
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SMILES
CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(NCCO)=O
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Synonyms
LTB4 ethanolamide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. McHugh D, et al., Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors. J Pharmacol Exp Ther. 2006 Feb;316(2):955-65. [Content Brief]
[2]. Bachi AL, et al., Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. Mol Cancer Res. 2009 Sep;7(9):1417-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leukotriene B4 ethanolamide Related Classifications
HY-131651 Related Classifications
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