2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Neprilysin

Neprilysin

Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10

Neprilysin

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Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106975
    SCH-42354
    		Inhibitor
    SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity.
    SCH-42354
  • HY-W013375S1
    Thiorphan-d5
    Thiorphan-d5 is deuterium labeled Thiorphan.
    Thiorphan-d<sub>5</sub>
  • HY-123782
    (Rac)-UK-414495
    		Inhibitor
    (Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female.
    (Rac)-UK-414495
  • HY-15407AS
    Sacubitril-13C4 hemicalcium salt
    		Inhibitor
    Sacubitril-13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696.
    Sacubitril-<sup>13</sup>C<sub>4</sub> hemicalcium salt
  • HY-139797
    SCH 47896
    		Inhibitor
    SCH 47896 is a phenolic derivative of SCH39370 (HY-139803), a potent specific inhibitor of metalloendopeptidase (NEP). SCH 47896 can be used for the research of cardiovascular disease, such as hypertension.
    SCH 47896
  • HY-19484
    GW 796406
    		Inhibitor
    GW 796406 is a novel vascular peptidase inhibitor. GW 796406’s inhibitory activity against NEP (IC50 ≈ 1.1-2.5 nM) is about three times that of ACE (IC50 ≈ 1.6-4.7 nM). GW 796406 can be used for research on cardiovascular conditions.
    GW 796406
  • HY-123150
    UK-447841
    		Inhibitor
    UK-447841 is a selective NEP inhibitor. UK-447841 can be used in the research of female sexual arousal disorder.
    UK-447841
  • HY-172904
    Antidiabetic agent 15
    		Inhibitor
    Antidiabetic agent 15 (compound 1B15) is a AT1R and NEP dual inhibitor. Antidiabetic agent 15 reduces the oxidative stress and restores the mitochondrial membrane potential.
    Antidiabetic agent 15
  • HY-19200
    RB-105
    		Inhibitor
    RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension.
    RB-105
  • HY-101682B
    (R)-SCH 42495
    		Inhibitor
    (R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
    (R)-SCH 42495
  • HY-N2021
    Phosphoramidon
    		Inhibitor
    Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
    Phosphoramidon
  • HY-117961
    Candoxatrilat
    		Inhibitor
    Candoxatrilat (UK 73967) is an orally active inhibitor of neutral endopeptidase. By elevating the levels of atrial natriuretic peptides, Candoxatrilat exerts its diuretic and natriuretic effects. Candoxatrilat is utilized in the research of heart failure.
    Candoxatrilat
  • HY-W747097
    Sacubitrilat-13C4
    		Inhibitor
    Sacubitrilat-13C4 (Desethyl Sacubitril-13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
    Sacubitrilat-<sup>13</sup>C<sub>4</sub>
  • HY-118264
    MDL-100240
    		Inhibitor
    MDL-100240 is a dual-acting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitor. MDL-100240 can significantly lower blood pressure, reverse left ventricular hypertrophy, and effectively prevent hypertrophy and dilatation of the aorta and resistance arteries, with an effect comparable to that of ramipril (HY-B0279). In addition, MDL-100240 can also reduce aldosterone levels, but has no significant effect on atrial natriuretic peptide and cGMP. In 3-month-old transgenic rats, MDL-100240 can reduce adrenomedullin concentrations, prevent and reverse severe hypertension and cardiovascular damage, and enhance bradykinin effects.
    MDL-100240
  • HY-114941
    Aladotril
    		Inhibitor
    Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction.
    Aladotril
  • HY-17620R
    Sacubitrilat (Standard)
    		Inhibitor
    Sacubitrilat (Standard) is the analytical standard of Sacubitrilat. This product is intended for research and analytical applications. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
    Sacubitrilat (Standard)
  • HY-10827R
    Kelatorphan (Standard)
    		Inhibitor
    Kelatorphan (Standard) is the analytical standard of Kelatorphan (HY-10827). This product is intended for research and analytical applications. Kelatorphan is a full inhibitor of enkephalin degrading enzymes.
    Kelatorphan (Standard)
  • HY-105351
    CGS25155
    		Inhibitor
    CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research.
    CGS25155
  • HY-114635
    Dexecadotril
    		Inhibitor
    Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action.
    Dexecadotril
  • HY-15407AS2
    Sacubitril-d5 hemicalcium
    		Inhibitor
    Sacubitril-d5 (AHU-377-d5) hemicalcium is deuterium-labeled Sacubitril hemicalcium (HY-15407A).
    Sacubitril-d<sub>5</sub> hemicalcium
Cat. No. Product Name / Synonyms Species Source