2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121828
    TX-1123
    		Inhibitor
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
    TX-1123
  • HY-131305
    HBDDE
    		Inhibitor 98.03%
    HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
    HBDDE
  • HY-130305
    GSK-938890A
    GSK-938890A is a PRK1 inhibitor with an IC50 of 3600 nM. GSK-938890A is applicable to research related to prostate cancer.
    GSK-938890A
  • HY-P10967
    EGFR Peptide
    EGFR Peptide is a selective substrate peptide for PKC. EGFR Peptide can used to measure PKC activity.
    EGFR Peptide
  • HY-P1402
    [Glu27]-PKC (19-36)
    [Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids.
    [Glu27]-PKC (19-36)
  • HY-N9097
    Niazirin
    		Inhibitor 99.9%
    Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
    Niazirin
  • HY-P1284A
    ZIP TFA
    		Inhibitor
    ZIP TFA is a selective peptide inhibitor of PKMζ. ZIP TFA injections can block the impairment in morphine conditioned place preference induced.
    ZIP TFA
  • HY-149490
    AJH-836
    		Activator
    AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM for PKCα) . AJH-836 triggers the translocation of Munc13-1 from the cytoplasm to the plasma membrane. AJH-836 can be used for research of neurodegenerative diseases.
    AJH-836
  • HY-RS11139
    Prkcq Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcq Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcq gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcq Rat Pre-designed siRNA Set A
  • HY-130305A
    GSK-943949A
    		Inhibitor
    GSK-943949A is a PRK1 inhibitor with an IC50 of 40.0 nM. GSK-943949A is applicable to research related to prostate cancer.
    GSK-943949A
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    		Inhibitor
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-RS11127
    Prkce Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkce Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkce gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkce Rat Pre-designed siRNA Set A
  • HY-RS11123
    Prkcd Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcd Mouse Pre-designed siRNA Set A
  • HY-N13747
    Chrysosplenol C
    		Activator
    Chrysosplenol C is a type of flavonoid compound. Chrysosplenol C selectively activates cardiac myosin ATPase, with its EC50 being 45 µM. Chrysosplenol C enhances the release of intracellular calcium ions by activating protein kinase C (PKC), thereby increasing the contractility of rat ventricular muscle cells. Chrysosplenol C can be used in the research of heart failure.
    Chrysosplenol C
  • HY-P3841
    Protein Kinase C β Peptide
    Protein Kinase C (beta) Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia.
    Protein Kinase C β Peptide
  • HY-108601
    (S)-Ro 32-0432 free base
    		Inhibitor
    (S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research.
    (S)-Ro 32-0432 free base
  • HY-RS11137
    PRKCQ Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCQ Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCQ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCQ Human Pre-designed siRNA Set A
  • HY-115769
    1,2-Didecanoylglycerol
    		Activator
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC).
    1,2-Didecanoylglycerol
  • HY-W720917
    Junicedric acid
    		Activator
    Junicedric acid is a diterpenoid compound that can be isolated from the resin of the Araucaria araucana tree. Junicedric acid exerts neuroprotective activity by increasing intracellular calcium levels in hippocampal neurons, activating PKC and calcium/calmodulin-dependent protein kinase (CaMKII), and preventing Amyloid-β oligomer-induced synaptic protein loss, apoptosis, and long-term potentiation (LTP) inhibition. Junicedric acid can be used in the study of the pathological mechanisms of neurodegenerative diseases such as Alzheimer's disease.
    Junicedric acid
  • HY-P5877
    ɛPKC(85–92),Myristoylated
    		Activator
    PKC(85–92),Myristoylated is a cell permeable myristic acid conjugated PKC peptide activator that enhances NO release in cultured human umbilical vein endothelial cells (HUVECs).
    ɛPKC(85–92),Myristoylated
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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