Chrysosplenol C
Chrysosplenol C is a type of flavonoid compound. Chrysosplenol C selectively activates cardiac myosin ATPase, with its EC50 being 45 µM. Chrysosplenol C enhances the release of intracellular calcium ions by activating protein kinase C (PKC), thereby increasing the contractility of rat ventricular muscle cells. Chrysosplenol C can be used in the research of heart failure.
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- CAS. Nr.: 23370-16-3
- Formel: C18H16O8
- Molecular Weight:360.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | ED50 |
11.2 μg/mL
Compound: chrysosplenol C
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Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
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[PMID: 1955888] |
Chemical Information
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CAS. Nr. 23370-16-3
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Molecular Weight 360.31
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Formel C18H16O8
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SMILES
O=C1C(OC)=C(C2=CC(OC)=C(O)C=C2)OC3=CC(OC)=C(C(O)=C13)O
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Venkateswararao E, et al. Exploration of Pharmacophore in Chrysosplenol C as Activator in Ventricular Myocyte Contraction. ACS Med Chem Lett. 2015 May 20;6(7):758-63. [Content Brief]
[2]. Wang J, et al. Chrysosplenol-C Increases Contraction by Augmentation of Sarcoplasmic Reticulum Ca2+ Loading and Release via Protein Kinase C in Rat Ventricular Myocytes. Mol Pharmacol. 2022 Jan;101(1):13-23. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chrysosplenol C Related Classifications
HY-N13747 Related Classifications
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