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Pim Related Products (53)
Related Products (53)
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SGI-1776
0 ImagesCat. No.: HY-13287ACAS No.: 1173928-26-1SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively.
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PC-046
0 ImagesCat. No.: HY-120561CAS No.: 1202401-59-9PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice.
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Pim-1 kinase inhibitor 6
0 ImagesCat. No.: HY-149996CAS No.: 2928606-69-1Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells.
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MNK/PIM-IN-2
0 ImagesCat. No.: HY-182957CAS No.: 3081482-46-1MNK/PIM-IN-2 is a Mnk/Pim kinase inhibitor with an IC50 of 32 nM for Mnk1, 3 nM for Mnk2, and 37 nM for Pim1. MNK/PIM-IN-2 reduces the levels of p-eIF4E and p-4EBP1. MNK/PIM-IN-2 induces cell cycle arrest, apoptosis (apoptosis) and exerts antiproliferative effects in leukemia cells. MNK/PIM-IN-2 can be used in studies related to leukemia.
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Pim-1 kinase inhibitor 1
0 ImagesCat. No.: HY-143295CAS No.: 2803505-57-7Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer.
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PIM-IN-4
0 ImagesCat. No.: HY-18088CAS No.: 1036380-87-6
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Pim-1 kinase inhibitor 10
0 ImagesCat. No.: HY-162059CAS No.: 2918764-57-3Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation.
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Uzansertib phosphate (Standard)
0 ImagesSynonyms: INCB053914 phosphate (Standard)Uzansertib phosphate (Standard) is the analytical standard of Uzansertib phosphate (HY-101870B). This product is intended for research and analytical applications. Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines.
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Quercetagetin (Standard)
0 ImagesQuercetagetin (Standard) is the analytical standard of Quercetagetin. This product is intended for research and analytical applications. Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
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Pim1/AKK1-IN-1 (Standard)
0 ImagesCat. No.: HY-10371RCAS No.: 1093222-27-5Synonyms: LKB1/AAK1 dual inhibitor (Standard)Pim1/AKK1-IN-1 (Standard) is the analytical standard of Pim1/AKK1-IN-1 (HY-10371). This product is intended for research and analytical applications. Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
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SMI-16a (Standard)
0 ImagesCat. No.: HY-101947RCAS No.: 587852-28-6Synonyms: PIM1/2 Kinase Inhibitor VI (Standard)
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PIM1-IN-1 (Standard)
0 ImagesCat. No.: HY-111552RCAS No.: 1417630-95-5PIM1-IN-1 (Standard) is the analytical standard of PIM1-IN-1 (HY-111552). This product is intended for research and analytical applications. PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity.
